Mezigdomide

DB17584InvestigationalSmall molecule

Mezigdomide is under investigation in clinical trial NCT05372354 (A Study to Evaluate Safety, Drug Levels and Effectiveness of CC-92480 (BMS-986348) in Combination With Other Treatments in Participants With Relapsed or...

Mechanism: Pharmacologically active on Protein cereblon, Zinc finger protein Aiolos, and DNA-binding protein Ikaros
Curator reviewed
Formula / weight: C₃₂H₃₀FN₅O₄ · 567.621 g/mol (avg)
Also known as: 4-(4-((4-(((2-((3s)-2,6-dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1h-isoindol-4- yl)oxy)methyl)phenyl)methyl)piperazin-1-yl)-3-fluorobenzonitrile · Benzonitrile, 4-(4-((4-(((2-((3s)-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1h-isoindol-4-yl)oxy)methyl)phenyl)methyl)-1-piperazinyl)-3-fluoro-
Code names: BMS-986348 · CC-92480

Resolves to

Compound

UNIILA88IH4O02CAS2259648-80-9ChEMBLCHEMBL4648616

Structure

InChIKeyYTINZZFBHWSAGL-NDEPHWFRSA-NSMILESFC1=CC(=CC=C1N1CCN(CC2=CC=C(COC3=CC=CC4=C3CN([C@H]3CCC(=O)NC3=O)C4=O)C=C2)CC1)C#N

Targets

Q96SW2CRBNQ9UKT9IKZF3Q13422IKZF1

What you can answer from here — as of July 08, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

20Clinical trialsPhase, status and sponsor resolved per trial

12+ReferencesStructured and connected to the statements they support

Which drugs share a target with Mezigdomide, and which of those have an active Phase 3 trial?

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