Inducible T-cell costimulator

BE0010660ProteinHumansICOS

Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response (PubMed:9930702). It is acted on by 6 drugs in DrugBank.

Gene name
ICOS
UniProtKB entry
Q9Y6W8Swiss-Prot
Cellular location
Cell membrane
Residues / weight
199 residues · 22,624 Da
Also known as
Activation-inducible lymphocyte immunomediatory molecule · AILIM

Resolves to

Protein
UniProtQ9Y6W8UniProt nameICOS_HUMAN
Gene
HGNCHGNC:5351NCBI Gene29851GeneCardsICOS
Pharmacology
IUPHAR/GtoPdb2939KEGGhsa:29851
Structure
PDB6X4GPDB7JOO
Drugs

What you can answer from here — as of October 31, 2023

6DrugsApproved to experimental, with action, bond type and pharmacological action
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6Clinical trialsTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Inducible T-cell costimulator, and which indications are they being tested in?

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