Acazicolcept

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Acazicolcept
DrugBank Accession Number
DB18410
Background

Not Available

Type
Biotech
Groups
Investigational
Biologic Classification
Protein Based Therapies
Fusion proteins
Protein Chemical Formula
Not Available
Protein Average Weight
Not Available
Sequences
Not Available
Synonyms
  • 1-122-INDUCIBLE COSTIMULATORY LIGAND PROTEIN (52-HISTIDINE,57-TYROSINE,100-ARGININE) (HUMAN) FUSION PROTEIN WITH SYNTHETIC PEPTIDE LINKER (GGGGSGGGGS) FUSION PROTEIN WITH IMMUNOGLOBULIN G1 (HUMAN .GAMMA.1-CHAIN C REGION VARIANT C-TERMINAL FRAGMENT), DIMER
  • Fc fusion protein of a human inducible T cell costimulator ligand variant immunoglobulin domain designed to inhibit simultaneously the CD28 and ICOS inflammation pathways
  • HUMAN INDUCIBLE T-CELL CO-STIMULATOR LIGAND (ICOS LIGAND) N-TERMINAL FRAGMENT (1-122) (VARIANT (N52>H, N57>Y, Q100>R), FUSED VIA PEPTIDYL LINKER 123GGGGSGGGGS132 TO A HUMAN IMMUNOGLOBULIN G1 FC FRAGMENT (133-363) VARIANT (C137>S, L151>A, L152>E, G154>A,
External IDs
  • ALPN 101
  • ALPN-101
  • ALPN101

Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
Not Available
Kingdom
Organic Compounds
Super Class
Organic Acids
Class
Carboxylic Acids and Derivatives
Sub Class
Amino Acids, Peptides, and Analogues
Direct Parent
Peptides
Alternative Parents
Not Available
Substituents
Not Available
Molecular Framework
Not Available
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
W507556HV0
CAS number
2270247-50-0

References

General References
Not Available
Not Available

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
2RecruitingTreatmentSystemic Lupus Erythematosus1
1CompletedOtherHealthy Subjects (HS)1
1TerminatedTreatmentGraft-versus-host Disease (GVHD)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available

Drug created at September 22, 2023 13:39 / Updated at September 24, 2023 02:56