Baculoviral IAP repeat-containing protein 3
Details
- Name
- Baculoviral IAP repeat-containing protein 3
- Kind
- protein
- Synonyms
- 2.3.2.27
- API2
- Apoptosis inhibitor 2
- C-IAP2
- Cellular inhibitor of apoptosis 2
- hIAP-1
- hIAP1
- IAP homolog C
- Inhibitor of apoptosis protein 1
- MIHC
- RING finger protein 49
- RING-type E3 ubiquitin transferase BIRC3
- RNF49
- TNFR2-TRAF-signaling complex protein 1
- Gene Name
- BIRC3
- UniProtKB Entry
- Q13489Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0053633|Baculoviral IAP repeat-containing protein 3 MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGV NDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNS THSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWP LTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQ DTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLR CWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESS IIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDL LNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHD VIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVS DLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVR TFLS
- Number of residues
- 604
- Molecular Weight
- 68370.865
- Theoretical pI
- Not Available
- GO Classification
- Processescanonical NF-kappaB signal transduction / non-canonical NF-kappaB signal transduction / positive regulation of canonical NF-kappaB signal transduction / regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
- General Function
- Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8
- Specific Function
- Cysteine-type endopeptidase inhibitor activity involved in apoptotic process
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0053634|Baculoviral IAP repeat-containing protein 3 (BIRC3) ATGAACATAGTAGAAAACAGCATATTCTTATCAAATTTGATGAAAAGCGCCAACACGTTT GAACTGAAATACGACTTGTCATGTGAACTGTACCGAATGTCTACGTATTCCACTTTTCCT GCTGGGGTTCCTGTCTCAGAAAGGAGTCTTGCTCGTGCTGGTTTCTATTACACTGGTGTG AATGACAAGGTCAAATGCTTCTGTTGTGGCCTGATGCTGGATAACTGGAAAAGAGGAGAC AGTCCTACTGAAAAGCATAAAAAGTTGTATCCTAGCTGCAGATTCGTTCAGAGTCTAAAT TCCGTTAACAACTTGGAAGCTACCTCTCAGCCTACTTTTCCTTCTTCAGTAACAAATTCC ACACACTCATTACTTCCGGGTACAGAAAACAGTGGATATTTCCGTGGCTCTTATTCAAAC TCTCCATCAAATCCTGTAAACTCCAGAGCAAATCAAGATTTTTCTGCCTTGATGAGAAGT TCCTACCACTGTGCAATGAATAACGAAAATGCCAGATTACTTACTTTTCAGACATGGCCA TTGACTTTTCTGTCGCCAACAGATCTGGCAAAAGCAGGCTTTTACTACATAGGACCTGGA GACAGAGTGGCTTGCTTTGCCTGTGGTGGAAAATTGAGCAATTGGGAACCGAAGGATAAT GCTATGTCAGAACACCTGAGACATTTTCCCAAATGCCCATTTATAGAAAATCAGCTTCAA GACACTTCAAGATACACAGTTTCTAATCTGAGCATGCAGACACATGCAGCCCGCTTTAAA ACATTCTTTAACTGGCCCTCTAGTGTTCTAGTTAATCCTGAGCAGCTTGCAAGTGCGGGT TTTTATTATGTGGGTAACAGTGATGATGTCAAATGCTTTTGCTGTGATGGTGGACTCAGG TGTTGGGAATCTGGAGATGATCCATGGGTTCAACATGCCAAGTGGTTTCCAAGGTGTGAG TACTTGATAAGAATTAAAGGACAGGAGTTCATCCGTCAAGTTCAAGCCAGTTACCCTCAT CTACTTGAACAGCTGCTATCCACATCAGACAGCCCAGGAGATGAAAATGCAGAGTCATCA ATTATCCATTTTGAACCTGGAGAAGACCATTCAGAAGATGCAATCATGATGAATACTCCT GTGATTAATGCTGCCGTGGAAATGGGCTTTAGTAGAAGCCTGGTAAAACAGACAGTTCAG AGAAAAATCCTAGCAACTGGAGAGAATTATAGACTAGTCAATGATCTTGTGTTAGACTTA CTCAATGCAGAAGATGAAATAAGGGAAGAGGAGAGAGAAAGAGCAACTGAGGAAAAAGAA TCAAATGATTTATTATTAATCCGGAAGAATAGAATGGCACTTTTTCAACATTTGACTTGT GTAATTCCAATCCTGGATAGTCTACTAACTGCCGGAATTATTAATGAACAAGAACATGAT GTTATTAAACAGAAGACACAGACGTCTTTACAAGCAAGAGAACTGATTGATACGATTTTA GTAAAAGGAAATATTGCAGCCACTGTATTCAGAAACTCTCTGCAAGAAGCTGAAGCTGTG TTATATGAGCATTTATTTGTGCAACAGGACATAAAATATATTCCCACAGAAGATGTTTCA GATCTACCAGTGGAAGAACAATTGCGGAGACTACAAGAAGAAAGAACATGTAAAGTGTGT ATGGACAAAGAAGTGTCCATAGTGTTTATTCCTTGTGGTCATCTAGTAGTATGCAAAGAT TGTGCTCCTTCTTTAAGAAAGTGTCCTATTTGTAGGAGTACAATCAAGGGTACAGTTCGT ACATTTCTTTCATGA
- Chromosome Location
- 11
- Locus
- 11q22.2
- External Identifiers
Resource Link UniProtKB ID Q13489 UniProtKB Entry Name BIRC3_HUMAN GeneCard ID BIRC3 HGNC ID HGNC:591 PDB ID(s) 2UVL, 3EB5, 3EB6, 3M0A, 3M0D, 7NK0 KEGG ID hsa:330 IUPHAR/Guide To Pharmacology ID 2792 NCBI Gene ID 330 - General References
- Not Available