Baculoviral IAP repeat-containing protein 3

BE0010674ProteinHumansBIRC3

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. It is acted on by 3 drugs in DrugBank.

Gene name
BIRC3
UniProtKB entry
Q13489Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
604 residues · 68,371 Da
Also known as
2.3.2.27 · API2 · Apoptosis inhibitor 2 · C-IAP2 · Cellular inhibitor of apoptosis 2

Resolves to

Protein
UniProtQ13489UniProt nameBIRC3_HUMAN
Gene
HGNCHGNC:591NCBI Gene330GeneCardsBIRC3
Pharmacology
IUPHAR/GtoPdb2792KEGGhsa:330
Structure
PDB2UVLPDB3EB5PDB3EB6
Drugs

What you can answer from here — as of October 31, 2023

3DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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22GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Baculoviral IAP repeat-containing protein 3, and which indications are they being tested in?

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