Mucosa-associated lymphoid tissue lymphoma translocation protein 1

BE0010702ProteinHumansMALT1

Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways... It is acted on by 1 drug in DrugBank.

Gene name
MALT1
UniProtKB entry
Q9UDY8Swiss-Prot
Cellular location
Cytoplasm, perinuclear region
Residues / weight
824 residues · 92,272 Da
Also known as
3.4.22.- · MALT lymphoma-associated translocation · MLT · Paracaspase

Resolves to

Protein
UniProtQ9UDY8UniProt nameMALT1_HUMAN
Gene
HGNCHGNC:6819NCBI Gene10892GeneCardsMALT1
Pharmacology
IUPHAR/GtoPdb2983KEGGhsa:10892
Structure
PDB2G7RPDB3BFOPDB3K0W
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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4GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Mucosa-associated lymphoid tissue lymphoma translocation protein 1, and which indications are they being tested in?

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