Baculoviral IAP repeat-containing protein 7
Details
- Name
- Baculoviral IAP repeat-containing protein 7
- Kind
- protein
- Synonyms
- 2.3.2.27
- KIAP
- Kidney inhibitor of apoptosis protein
- LIVIN
- Melanoma inhibitor of apoptosis protein
- ML-IAP
- MLIAP
- RING finger protein 50
- RING-type E3 ubiquitin transferase BIRC7
- RNF50
- Gene Name
- BIRC7
- UniProtKB Entry
- Q96CA5Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0053699|Baculoviral IAP repeat-containing protein 7 MGPKDSAKCLHRGPQPSHWAAGDGPTQERCGPRSLGSPVLGLDTCRAWDHVDGQILGQLR PLTEEEEEEGAGATLSRGPAFPGMGSEELRLASFYDWPLTAEVPPELLAAAGFFHTGHQD KVRCFFCYGGLQSWKRGDDPWTEHAKWFPSCQFLLRSKGRDFVHSVQETHSQLLGSWDPW EEPEDAAPVAPSVPASGYPELPTPRREVQSESAQEPGGVSPAEAQRAWWVLEPPGARDVE AQLRRLQEERTCKVCLDRAVSIVFVPCGHLVCAECAPGLQLCPICRAPVRSRVRTFLS
- Number of residues
- 298
- Molecular Weight
- 32797.655
- Theoretical pI
- Not Available
- GO Classification
- Not Available
- General Function
- Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control (PubMed:11024045, PubMed:11084335, PubMed:11162435, PubMed:16729033, PubMed:17294084). Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity (PubMed:11024045, PubMed:16729033). As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival (PubMed:16729033). May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions (PubMed:16729033). Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine (PubMed:11084335, PubMed:11162435, PubMed:11865055). Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2 (PubMed:11865055). This activation depends on TAB1 and MAP3K7/TAK1 (PubMed:11865055). In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9 (PubMed:11024045)
- Specific Function
- Cysteine-type endopeptidase inhibitor activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0053700|Baculoviral IAP repeat-containing protein 7 (BIRC7) ATGGGACCTAAAGACAGTGCCAAGTGCCTGCACCGTGGACCACAGCCGAGCCACTGGGCA GCCGGTGATGGTCCCACGCAGGAGCGCTGTGGACCCCGCTCTCTGGGCAGCCCTGTCCTA GGCCTGGACACCTGCAGAGCCTGGGACCACGTGGATGGGCAGATCCTGGGCCAGCTGCGG CCCCTGACAGAGGAGGAAGAGGAGGAGGGCGCCGGGGCCACCTTGTCCAGGGGGCCTGCC TTCCCCGGCATGGGCTCTGAGGAGTTGCGTCTGGCCTCCTTCTATGACTGGCCGCTGACT GCTGAGGTGCCACCCGAGCTGCTGGCTGCTGCCGGCTTCTTCCACACAGGCCATCAGGAC AAGGTGAGGTGCTTCTTCTGCTATGGGGGCCTGCAGAGCTGGAAGCGCGGGGACGACCCC TGGACGGAGCATGCCAAGTGGTTCCCCAGCTGTCAGTTCCTGCTCCGGTCAAAAGGAAGA GACTTTGTCCACAGTGTGCAGGAGACTCACTCCCAGCTGCTGGGCTCCTGGGACCCGTGG GAAGAACCGGAAGACGCAGCCCCTGTGGCCCCCTCCGTCCCTGCCTCTGGGTACCCTGAG CTGCCCACACCCAGGAGAGAGGTCCAGTCTGAAAGTGCCCAGGAGCCAGGAGGGGTCAGT CCAGCCGAGGCCCAGAGGGCGTGGTGGGTTCTTGAGCCCCCAGGAGCCAGGGATGTGGAG GCGCAGCTGCGGCGGCTGCAGGAGGAGAGGACGTGCAAGGTGTGCCTGGACCGCGCCGTG TCCATCGTCTTTGTGCCGTGCGGCCACCTGGTCTGTGCTGAGTGTGCCCCCGGCCTGCAG CTGTGCCCCATCTGCAGAGCCCCCGTCCGCAGCCGCGTGCGCACCTTCCTGTCCTAG
- Chromosome Location
- 20
- Locus
- 20q13.33
- External Identifiers
Resource Link UniProtKB ID Q96CA5 UniProtKB Entry Name BIRC7_HUMAN GeneCard ID BIRC7 HGNC ID HGNC:13702 PDB ID(s) 1OXN, 1OXQ, 1OY7, 1TW6, 2I3H, 2I3I, 3F7G, 3F7H, 3F7I, 3GT9, 3GTA, 3UW5, 4AUQ KEGG ID hsa:79444 IUPHAR/Guide To Pharmacology ID 2794 NCBI Gene ID 79444 - General References
- Not Available