Proteinase-activated receptor 2

BE0010726ProteinHumansF2RL1

Receptor for trypsin and trypsin-like enzymes coupled to G proteins (PubMed:28445455). It is acted on by 1 drug in DrugBank.

Gene name
F2RL1
UniProtKB entry
P55085Swiss-Prot
Cellular location
Cell membrane
Residues / weight
397 residues · 44,126 Da
Also known as
Coagulation factor II receptor-like 1 · G protein-coupled receptor 11 · GPR11 · PAR-2 · PAR2

Resolves to

Protein
UniProtP55085UniProt namePAR2_HUMAN
Gene
HGNCHGNC:3538NCBI Gene2150GeneCardsF2RL1
Pharmacology
IUPHAR/GtoPdb348KEGGhsa:2150
Structure
PDB5NDDPDB5NDZPDB5NJ6
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Proteinase-activated receptor 2, how selective are they, and which programs against it are still in active trials?

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