Growth/differentiation factor 11

BE0010786ProteinHumansGDF11

Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. It is acted on by 2 drugs in DrugBank.

Gene name
GDF11
UniProtKB entry
O95390Swiss-Prot
Cellular location
Secreted
Residues / weight
407 residues · 45,090 Da
Also known as
BMP-11 · BMP11 · Bone morphogenetic protein 11 · GDF-11

Resolves to

Protein
UniProtO95390UniProt nameGDF11_HUMAN
Gene
HGNCHGNC:4216NCBI Gene10220GeneCardsGDF11
Pharmacology
KEGGhsa:10220
Structure
PDB5E4GPDB5JHWPDB5UHM
Drugs

What you can answer from here — as of October 31, 2023

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Growth/differentiation factor 11, how selective are they, and which programs against it are still in active trials?

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