Transcription factor PU.1

BE0010802ProteinHumansSPI1

Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. It is acted on by 2 drugs in DrugBank.

Gene name
SPI1
UniProtKB entry
P17947Swiss-Prot
Cellular location
Nucleus
Residues / weight
270 residues · 31,083 Da
Also known as
31 kDa-transforming protein

Resolves to

Protein
UniProtP17947UniProt nameSPI1_HUMAN
Gene
HGNCHGNC:11241NCBI Gene6688GeneCardsSPI1
Pharmacology
KEGGhsa:6688
Structure
PDB8E3KPDB8E3RPDB8E4H
Drugs

What you can answer from here — as of October 31, 2023

2DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
1GO termFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
2+ReferencesStructured and connected to the statements they support
Sign in

Which compounds in development act on Transcription factor PU.1, and which indications are they being tested in?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In