Baculoviral IAP repeat-containing protein 1
Details
- Name
- Baculoviral IAP repeat-containing protein 1
- Kind
- protein
- Synonyms
- BIRC1
- Neuronal apoptosis inhibitory protein
- Gene Name
- NAIP
- UniProtKB Entry
- Q13075Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0053904|Baculoviral IAP repeat-containing protein 1 MATQQKASDERISQFDHNLLPELSALLGLDAVQLAKELEEEEQKERAKMQKGYNSQMRSE AKRLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHKRF HPDCGFLLNKDVGNIAKYDIRVKNLKSRLRGGKMRYQEEEARLASFRNWPFYVQGISPCV LSEAGFVFTGKQDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLRSKKSSEEITQYI QSYKGFVDITGEHFVNSWVQRELPMASAYCNDSIFAYEELRLDSFKDWPRESAVGVAALA KAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNCPFLQNMKSSAEVTPDLQS RGELCELLETTSESNLEDSIAVGPIVPEMAQGEAQWFQEAKNLNEQLRAAYTSASFRHMS LLDISSDLATDHLLGCDLSIASKHISKPVQEPLVLPEVFGNLNSVMCVEGEAGSGKTVLL KKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKEGSVTEMCVRNIIQ QLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVRTNRARDIRRYLETILEIK AFPFYNTVCILRKLFSHNMTRLRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPS FDDVAVFKSYMERLSLRNKATAEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDED EDLTMCLMSKFTAQRLRPFYRFLSPAFQEFLAGMRLIELLDSDRQEHQDLGLYHLKQINS PMMTVSAYNNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESLENISENDDYLKHQPEISLQ MQLLRGLWQICPQAYFSMVSEHLLVLALKTAYQSNTVAACSPFVLQFLQGRTLTLGALNL QYFFDHPESLSLLRSIHFPIRGNKTSPRAHFSVLETCFDKSQVPTIDQDYASAFEPMNEW ERNLAEKEDNVKSYMDMQRRASPDLSTGYWKLSPKQYKIPCLEVDVNDIDVVGQDMLEIL MTVFSASQRIELHLNHSRGFIESIRPALELSKASVTKCSISKLELSAAEQELLLTLPSLE SLEVSGTIQSQDQIFPNLDKFLCLKELSVDLEGNINVFSVIPEEFPNFHHMEKLLIQISA EYDPSKLVKLIQNSPNLHVFHLKCNFFSDFGSLMTMLVSCKKLTEIKFSDSFFQAVPFVA SLPNFISLKILNLEGQQFPDEETSEKFAYILGSLSNLEELILPTGDGIYRVAKLIIQQCQ QLHCLRVLSFFKTLNDDSVVEIAKVAISGGFQKLENLKLSINHKITEEGYRNFFQALDNM PNLQELDISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNMLSWLLDADDIALLNVMKER HPQSKYLTILQKWILPFSPIIQK
- Number of residues
- 1403
- Molecular Weight
- 159579.9
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP hydrolysis activity
- General Function
- Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy
- Specific Function
- Atp binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0053905|Baculoviral IAP repeat-containing protein 1 (NAIP) ATGGCCACCCAGCAGAAAGCCTCTGACGAGAGGATCTCCCAGTTTGATCACAATTTGCTG CCAGAGCTGTCTGCTCTTCTGGGCCTAGATGCAGTTCAGTTGGCAAAGGAACTAGAAGAA GAGGAGCAGAAGGAGCGAGCAAAAATGCAGAAAGGCTACAACTCTCAAATGCGCAGTGAA GCAAAAAGGTTAAAGACTTTTGTGACTTATGAGCCGTACAGCTCATGGATACCACAGGAG ATGGCGGCCGCTGGGTTTTACTTCACTGGGGTAAAATCTGGGATTCAGTGCTTCTGCTGT AGCCTAATCCTCTTTGGTGCCGGCCTCACGAGACTCCCCATAGAAGACCACAAGAGGTTT CATCCAGATTGTGGGTTCCTTTTGAACAAGGATGTTGGTAACATTGCCAAGTACGACATA AGGGTGAAGAATCTGAAGAGCAGGCTGAGAGGAGGTAAAATGAGGTACCAAGAAGAGGAG GCTAGACTTGCGTCCTTCAGGAACTGGCCATTTTATGTCCAAGGGATATCCCCTTGTGTG CTCTCAGAGGCTGGCTTTGTCTTTACAGGTAAACAGGACACGGTACAGTGTTTTTCCTGT GGTGGATGTTTAGGAAATTGGGAAGAAGGAGATGATCCTTGGAAGGAACATGCCAAATGG TTCCCCAAATGTGAATTTCTTCGGAGTAAGAAATCCTCAGAGGAAATTACCCAGTATATT CAAAGCTACAAGGGATTTGTTGACATAACGGGAGAACATTTTGTGAATTCCTGGGTCCAG AGAGAATTACCTATGGCATCAGCTTATTGCAATGACAGCATCTTTGCTTACGAAGAACTA CGGCTGGACTCTTTTAAGGACTGGCCCCGGGAATCAGCTGTGGGAGTTGCAGCACTGGCC AAAGCAGGTCTTTTCTACACAGGTATAAAGGACATCGTCCAGTGCTTTTCCTGTGGAGGG TGTTTAGAGAAATGGCAGGAAGGTGATGACCCATTAGACGATCACACCAGATGTTTTCCC AATTGTCCATTTCTCCAAAATATGAAGTCCTCTGCGGAAGTGACTCCAGACCTTCAGAGC CGTGGTGAACTTTGTGAATTACTGGAAACCACAAGTGAAAGCAATCTTGAAGATTCAATA GCAGTTGGTCCTATAGTGCCAGAAATGGCACAGGGTGAAGCCCAGTGGTTTCAAGAGGCA AAGAATCTGAATGAGCAGCTGAGAGCAGCTTATACCAGCGCCAGTTTCCGCCACATGTCT TTGCTTGATATCTCTTCCGATCTGGCCACGGACCACTTGCTGGGCTGTGATCTGTCTATT GCTTCAAAACACATCAGCAAACCTGTGCAAGAACCTCTGGTGCTGCCTGAGGTCTTTGGC AACTTGAACTCTGTCATGTGTGTGGAGGGTGAAGCTGGAAGTGGAAAGACGGTCCTCCTG AAGAAAATAGCTTTTCTGTGGGCATCTGGATGCTGTCCCCTGTTAAACAGGTTCCAGCTG GTTTTCTACCTCTCCCTTAGTTCCACCAGACCAGACGAGGGGCTGGCCAGTATCATCTGT GACCAGCTCCTAGAGAAAGAAGGATCTGTTACTGAAATGTGCGTGAGGAACATTATCCAG CAGTTAAAGAATCAGGTCTTATTCCTTTTAGATGACTACAAAGAAATATGTTCAATCCCT CAAGTCATAGGAAAACTGATTCAAAAAAACCACTTATCCCGGACCTGCCTATTGATTGCT GTCCGTACAAACAGGGCCAGGGACATCCGCCGATACCTAGAGACCATTCTAGAGATCAAA GCATTTCCCTTTTATAATACTGTCTGTATATTACGGAAGCTCTTTTCACATAATATGACT CGTCTGCGAAAGTTTATGGTTTACTTTGGAAAGAACCAAAGTTTGCAGAAGATACAGAAA ACTCCTCTCTTTGTGGCGGCGATCTGTGCTCATTGGTTTCAGTATCCTTTTGACCCATCC TTTGATGATGTGGCTGTTTTCAAGTCCTATATGGAACGCCTTTCCTTAAGGAACAAAGCG ACAGCTGAAATTCTCAAAGCAACTGTGTCCTCCTGTGGTGAGCTGGCCTTGAAAGGGTTT TTTTCATGTTGCTTTGAGTTTAATGATGATGATCTCGCAGAAGCAGGGGTTGATGAAGAT GAAGATCTAACCATGTGCTTGATGAGCAAATTTACAGCCCAGAGACTAAGACCATTCTAC CGGTTTTTAAGTCCTGCCTTCCAAGAATTTCTTGCGGGGATGAGGCTGATTGAACTCCTG GATTCAGATAGGCAGGAACATCAAGATTTGGGACTGTATCATTTGAAACAAATCAACTCA CCCATGATGACTGTAAGCGCCTACAACAATTTTTTGAACTATGTCTCCAGCCTCCCTTCA ACAAAAGCAGGGCCCAAAATTGTGTCTCATTTGCTCCATTTAGTGGATAACAAAGAGTCA TTGGAGAATATATCTGAAAATGATGACTACTTAAAGCACCAGCCAGAAATTTCACTGCAG ATGCAGTTACTTAGGGGATTGTGGCAAATTTGTCCACAAGCTTACTTTTCAATGGTTTCA GAACATTTACTGGTTCTTGCCCTGAAAACTGCTTATCAAAGCAACACTGTTGCTGCGTGT TCTCCATTTGTTTTGCAATTCCTTCAAGGGAGAACACTGACTTTGGGTGCGCTTAACTTA CAGTACTTTTTCGACCACCCAGAAAGCTTGTCATTGTTGAGGAGCATCCACTTCCCAATA CGAGGAAATAAGACATCACCCAGAGCACATTTTTCAGTTCTGGAAACATGTTTTGACAAA TCACAGGTGCCAACTATAGATCAGGACTATGCTTCTGCCTTTGAACCTATGAATGAATGG GAGCGAAATTTAGCTGAAAAAGAGGATAATGTAAAGAGCTATATGGATATGCAGCGCAGG GCATCACCAGACCTTAGTACTGGCTATTGGAAACTTTCTCCAAAGCAGTACAAGATTCCC TGTCTAGAAGTCGATGTGAATGATATTGATGTTGTAGGCCAGGATATGCTTGAGATTCTA ATGACAGTTTTCTCAGCTTCACAGCGCATCGAACTCCATTTAAACCACAGCAGAGGCTTT ATAGAAAGCATCCGCCCAGCTCTTGAGCTGTCTAAGGCCTCTGTCACCAAGTGCTCCATA AGCAAGTTGGAACTCAGCGCAGCCGAACAGGAACTGCTTCTCACCCTGCCTTCCCTGGAA TCTCTTGAAGTCTCAGGGACAATCCAGTCACAAGACCAAATCTTTCCTAATCTGGATAAG TTCCTGTGCCTGAAAGAACTGTCTGTGGATCTGGAGGGCAATATAAATGTTTTTTCAGTC ATTCCTGAAGAATTTCCAAACTTCCACCATATGGAGAAATTATTGATCCAAATTTCAGCT GAGTATGATCCTTCCAAACTAGTAAAATTAATTCAAAATTCTCCAAACCTTCATGTTTTC CATCTGAAGTGTAACTTCTTTTCGGATTTTGGGTCTCTCATGACTATGCTTGTTTCCTGT AAGAAACTCACAGAAATTAAGTTTTCGGATTCATTTTTTCAAGCCGTCCCATTTGTTGCC AGTTTGCCAAATTTTATTTCTCTGAAGATATTAAATCTTGAAGGCCAGCAATTTCCTGAT GAGGAAACATCAGAAAAATTTGCCTACATTTTAGGTTCTCTTAGTAACCTGGAAGAATTG ATCCTTCCTACTGGGGATGGAATTTATCGAGTGGCCAAACTGATCATCCAGCAGTGTCAG CAGCTTCATTGTCTCCGAGTCCTCTCATTTTTCAAGACTTTGAATGATGACAGCGTGGTG GAAATTGCCAAAGTAGCAATCAGTGGAGGTTTCCAGAAACTTGAGAACCTAAAGCTTTCA ATCAATCACAAGATTACAGAGGAAGGATACAGAAATTTCTTTCAAGCACTGGACAACATG CCAAACTTGCAGGAGTTGGACATCTCCAGGCATTTCACAGAGTGTATCAAAGCTCAGGCC ACAACAGTCAAGTCTTTGAGTCAATGTGTGTTACGACTACCAAGGCTCATTAGACTGAAC ATGTTAAGTTGGCTCTTGGATGCAGATGATATTGCATTGCTTAATGTCATGAAAGAAAGA CATCCTCAATCTAAGTACTTAACTATTCTCCAGAAATGGATACTGCCGTTCTCTCCAATC ATTCAGAAATAA
- Chromosome Location
- 5
- Locus
- 5q13.2
- External Identifiers
Resource Link UniProtKB ID Q13075 UniProtKB Entry Name BIRC1_HUMAN GeneCard ID NAIP HGNC ID HGNC:7634 PDB ID(s) 2VM5, 8FVU KEGG ID hsa:4671 NCBI Gene ID 4671 - General References
- Not Available