Histone-lysine N-methyltransferase, H3 lysine-79 specific

BE0010820ProteinHumansDOT1L

Histone methyltransferase that methylates 'Lys-79' of histone H3 (PubMed:12123582, PubMed:38503750, PubMed:38129415). It is acted on by 1 drug in DrugBank.

Gene name
DOT1L
UniProtKB entry
Q8TEK3Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,537 residues · 164,854 Da
Also known as
2.1.1.360 · Disruptor of telomeric silencing 1-like histone lysine methyltransferase · DOT1-like protein · H3-K79-HMTase · Histone H3-K79 methyltransferase

Resolves to

Protein
UniProtQ8TEK3UniProt nameDOT1L_HUMAN
Gene
HGNCHGNC:24948NCBI Gene84444GeneCardsDOT1L
Pharmacology
IUPHAR/GtoPdb2650KEGGhsa:84444
Structure
PDB1NW3PDB2MV7PDB3QOW
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Histone-lysine N-methyltransferase, H3 lysine-79 specific, and which indications are they being tested in?

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