Lysosomal alpha-mannosidase

BE0010829ProteinHumansMAN2B1

Can hydrolyze a variety of glycan substrates containing terminal alpha-mannosidic linkages. It is acted on by 2 drugs in DrugBank.

Gene name
MAN2B1
UniProtKB entry
O00754Swiss-Prot
Cellular location
Lysosome lumen
Residues / weight
1,011 residues · 113,743 Da
Also known as
3.2.1.24 · LAMAN · Lysosomal acid alpha-mannosidase · MANB · Mannosidase alpha class 2B member 1

Resolves to

Protein
UniProtO00754UniProt nameMA2B1_HUMAN
Gene
HGNCHGNC:6826NCBI Gene4125GeneCardsMAN2B1
Pharmacology
KEGGhsa:4125
Drugs

What you can answer from here — as of October 31, 2023

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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1GO termFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Lysosomal alpha-mannosidase, how selective are they, and which programs against it are still in active trials?

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