Double-strand break repair protein MRE11

BE0010840ProteinHumansMRE11

Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:11741547, PubMed:14657032, PubMed:22078559, PubMed:23080121, PubMed:24316220, PubMed:26240375, PubMed:27889449, PubMed:28867292, PubMed:29670289, PubMed:30464262, PubMed:30612738,... It is acted on by 1 drug in DrugBank.

Gene name
MRE11
UniProtKB entry
P49959Swiss-Prot
Cellular location
Nucleus
Residues / weight
708 residues · 80,593 Da
Also known as
3.1.-.- · HNGS1 · Meiotic recombination 11 homolog 1 · Meiotic recombination 11 homolog A · MRE11 homolog 1

Resolves to

Protein
UniProtP49959UniProt nameMRE11_HUMAN
Gene
HGNCHGNC:7230NCBI Gene4361GeneCardsMRE11
Pharmacology
KEGGhsa:4361
Structure
PDB3T1IPDB7ZQYPDB8BAH
Drugs

What you can answer from here — as of October 31, 2023

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Double-strand break repair protein MRE11, how selective are they, and which programs against it are still in active trials?

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