Pentamidine

DB00738ApprovedInvestigationalSmall moleculeAntiprotozoals

Pentamidine is an antifungal agent used to treat Pneumocystis pneumonia in patients infected with HIV. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.

Mechanism: The mode of action of pentamidine is not fully understood. It is thought that the drug interferes with nuclear metabolism producing inhibition of the synthesis of DNA, RNA, phospholipids, and proteins.
Curator reviewed
Primary indication: For the treatment of pneumonia due to Pneumocystis carinii.Curator reviewed · 5 structured indications
Formula / weight: C₁₉H₂₄N₄O₂ · 340.4195 g/mol (avg)
First approval: Canada, 2000 · United States, 1994
Code names: MB 800 · RP 2512
Brand names: Nebupent
Pentam

Resolves to

Compound

UNII673LC5J4LQCAS100-33-4ChEMBLCHEMBL55ChEBI45081PubChem4735KEGGC07420

Clinical / RWD

RxNorm7994ATCP01CX01PharmGKBPA450850

Structure

InChIKeyXDRYMKDFEDOLFX-UHFFFAOYSA-NSMILESNC(=N)C1=CC=C(OCCCCCOC2=CC=C(C=C2)C(N)=N)C=C1

Targets

P04271S100BP0C0J0speBQ92993KAT5P29475NOS1Q12809KCNH2P00747PLGP19801AOC1P08514ITGA2B+4 more

Transporters

O15245SLC22A1

What you can answer from here — as of September 23, 2026

14Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1TransporterSubstrate / inhibitor direction, not just membership

Listed above

1,893Drug interactionsStructured to mechanism, not free text

27Clinical trialsPhase, status and sponsor resolved per trial

5Structured indicationsCondition, population, route and combination as fields, not prose

19Marketed productsAcross 7 countries and 13 labellers

1ATC codeIncluding every combination product, plus 27 drug categories

31+ReferencesStructured and connected to the statements they support

Which drugs share a target with Pentamidine, and which of those have an active Phase 3 trial?

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