Cholesterol 24-hydroxylase

BE0010886ProteinHumansCYP46A1

P450 monooxygenase that plays a major role in cholesterol homeostasis in the brain. It is acted on by 3 drugs in DrugBank.

Gene name
CYP46A1
UniProtKB entry
Q9Y6A2Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
500 residues · 56,821 Da
Also known as
1.14.14.25 · CH24H · Cholesterol 24-monooxygenase · Cholesterol 24S-hydroxylase · CYP46

Resolves to

Protein
UniProtQ9Y6A2UniProt nameCP46A_HUMAN
Gene
HGNCHGNC:2641NCBI Gene10858GeneCardsCYP46A1
Pharmacology
IUPHAR/GtoPdb1373KEGGhsa:10858
Structure
PDB2Q9FPDB2Q9GPDB3MDM
Drugs

What you can answer from here — as of October 31, 2023

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
1Clinical trialTrials of drugs acting on it, by phase and status
Sign in
19GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
5+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Cholesterol 24-hydroxylase, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In