Soticlestat

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Soticlestat
DrugBank Accession Number
DB16987
Background

Not Available

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 373.456
Monoisotopic: 373.179026993
Chemical Formula
C23H23N3O2
Synonyms
Not Available
External IDs
  • OV-935
  • OV935
  • TAK-935
  • TAK935

Pharmacology

Indication

Not Available

Reduce drug development failure rates
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
1766MU795L
CAS number
1429505-03-2
InChI Key
XKUZMIUSBMCVPP-UHFFFAOYSA-N
InChI
InChI=1S/C23H23N3O2/c27-22(20-7-4-12-25-21(20)19-8-13-24-14-9-19)26-15-10-23(28,11-16-26)17-18-5-2-1-3-6-18/h1-9,12-14,28H,10-11,15-17H2
IUPAC Name
4-benzyl-1-{[2,4'-bipyridine]-3-carbonyl}piperidin-4-ol
SMILES
OC1(CC2=CC=CC=C2)CCN(CC1)C(=O)C1=CC=CN=C1C1=CC=NC=C1

References

General References
Not Available
ChemSpider
68007185
ChEMBL
CHEMBL4298172
PDBe Ligand
YBS
PDB Entries
7lrl

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentDravet Syndrome (DS)1
3CompletedTreatmentLennox-Gastaut Syndrome1
3RecruitingTreatmentDravet Syndrome (DS) / Lennox-Gastaut Syndrome2
2Active Not RecruitingTreatmentDravet Syndrome (DS) / Epilepsy / Lennox-Gastaut Syndrome1
2CompletedTreatmentCDKL5 Deficiency Disease / Dup15Q Syndrome1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.071 mg/mLALOGPS
logP2.11ALOGPS
logP2.12Chemaxon
logS-3.7ALOGPS
pKa (Strongest Acidic)14.58Chemaxon
pKa (Strongest Basic)3.91Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count4Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area66.32 Å2Chemaxon
Rotatable Bond Count4Chemaxon
Refractivity108.36 m3·mol-1Chemaxon
Polarizability40.62 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
Not Available

Drug created at September 16, 2022 23:17 / Updated at December 01, 2022 11:33