Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

BE0010899ProteinHumansHCN1

Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions (PubMed:15351778, PubMed:28086084). It is acted on by 4 drugs in DrugBank.

Gene name
HCN1
UniProtKB entry
O60741Swiss-Prot
Cellular location
Cell membrane
Residues / weight
890 residues · 98,795 Da
Also known as
BCNG-1 · BCNG1 · Brain cyclic nucleotide-gated channel 1

Resolves to

Protein
UniProtO60741UniProt nameHCN1_HUMAN
Gene
HGNCHGNC:4845NCBI Gene348980GeneCardsHCN1
Pharmacology
IUPHAR/GtoPdb400KEGGhsa:348980
Structure
PDB5U6OPDB5U6PPDB6UQF
Drugs

What you can answer from here — as of October 31, 2023

4DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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23GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, how selective are they, and which programs against it are still in active trials?

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