Cilobradine

DB20039InvestigationalSmall molecule

Cilobradine is a small molecule drug. The usage of the INN stem '-bradine' in the name indicates that Cilobradine is a bradycardic agent. Cilobradine is under investigation in clinical trial... Cilobradine is under investigation in clinical trial NCT02264041 (Effect of Cytochrome P 450 3A4 Inhibition by Itraconazole on the Single Oral Dose Pharmacokinetics of Cilobradine).

Mechanism: Pharmacologically active on Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, and Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
Curator reviewed
Formula / weight: C₂₈H₃₈N₂O₅ · 482.621 g/mol (avg)

Resolves to

Compound

UNII5O1LL04GJ3CAS147541-45-5ChEMBLCHEMBL1436376ChEBI749808PubChem9869877

Structure

InChIKeyOBUFMJDDZTXJPY-NRFANRHFSA-NSMILESCOC1=CC=C(CCN2CCC[C@H](CN3CCC4=C(CC3=O)C=C(OC)C(OC)=C4)C2)C=C1OC

Targets

Q9UL51HCN2O60741HCN1Q9P1Z3HCN3Q9Y3Q4HCN4

What you can answer from here — as of September 23, 2026

4Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1Clinical trialPhase, status and sponsor resolved per trial

5+ReferencesStructured and connected to the statements they support

Which drugs share a target with Cilobradine, and which of those have an active Phase 3 trial?

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