Apoptosis regulator Bcl-2

BE0010919ProteinRatBcl2

Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. It is acted on by 2 drugs in DrugBank.

Gene name: Bcl2
UniProtKB entry: P49950Swiss-Prot
Cellular location: Mitochondrion outer membrane
Residues / weight: 236 residues · 26,622 Da
Also known as: Bcl-2

Resolves to

Protein

UniProtP49950UniProt nameBCL2_RAT

Gene

NCBI Gene24224

Pharmacology

KEGGrno:24224

Drugs

What you can answer from here — as of November 01, 2023

2DrugsApproved to experimental, with action, bond type and pharmacological action

222GO termsFunction, process and component, as structured annotations

2Pfam domainsDomain architecture mapped to Pfam families and clans

7+ReferencesStructured and connected to the statements they support

Which compounds in development act on Apoptosis regulator Bcl-2, and which indications are they being tested in?

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