Toxin A

BE0010938ProteinPeptoclostridium difficiletcdA

Toxin A Precursor of a cytotoxin that targets and disrupts the colonic epithelium, inducing the host inflammatory and innate immune responses and resulting in diarrhea and pseudomembranous colitis (PubMed:20844489). It is acted on by 2 drugs in DrugBank.

Gene name
tcdA
UniProtKB entry
P16154Swiss-Prot
Cellular location
Secreted
Residues / weight
2,710 residues · 308,053 Da
Also known as
3.4.22.- · toxA

Resolves to

Protein
UniProtP16154UniProt nameTCDA_CLODI
Structure
PDB2F6EPDB2G7CPDB2QJ6
Drugs

What you can answer from here — as of November 01, 2023

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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20GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Toxin A, how selective are they, and which programs against it are still in active trials?

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