Cadherin-11

Details

Name

Cadherin-11

Kind

protein

Synonyms

• OB-cadherin
• OSF-4
• Osteoblast cadherin

Gene Name

CDH11

UniProtKB Entry

P55287Swiss-Prot

Organism

Humans

NCBI Taxonomy ID

9606

Amino acid sequence

>lcl|BSEQ0054186|Cadherin-11
MKENYCLQAALVCLGMLCHSHAFAPERRGHLRPSFHGHHEKGKEGQVLQRSKRGWVWNQF
FVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSGNIHATKTLDREE
RAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANVPERSNVGTSVIQ
VTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREAKEEYHVVIQAKD
MGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVGRVKAKDPDIGEN
GLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVEAANVHIDPKFIS
NGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAKDPDAANSPIRYS
IDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHNRHQEAKVPVAIRVLD
VNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANGPRFIFSLPPEIIHNPN
FTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSSTNTLTIKVCGCDVNGA
LLSCNAEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQKKEPLIVFEEEDVRENI
ITYDDEGGGEEDTEAFDIATLQNPDGINGFIPRKDIKPEYQYMPRPGLRPAPNSVDVDDF
INTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESATTDSDLDYDYLQNWGPRFK
KLADLYGSKDTFDDDS

Number of residues

796

Molecular Weight

87964.545

Theoretical pI

Not Available

GO Classification

Functions

beta-catenin binding

General Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly (PubMed:33811546). Involved in the regulation of cell migration (PubMed:33811546)

Specific Function

beta-catenin binding

Pfam Domain Function

• Cadherin (PF00028)
• CADH_Y-type_LIR (PF01049)

Signal Regions

1-22

Transmembrane Regions

618-640

Cellular Location

Cell membrane

Gene sequence

>lcl|BSEQ0054187|Cadherin-11 (CDH11)
ATGAAGGAGAACTACTGTTTACAAGCCGCCCTGGTGTGCCTGGGCATGCTGTGCCACAGC
CATGCCTTTGCCCCAGAGCGGCGGGGGCACCTGCGGCCCTCCTTCCATGGGCACCATGAG
AAGGGCAAGGAGGGGCAGGTGCTACAGCGCTCCAAGCGTGGCTGGGTCTGGAACCAGTTC
TTCGTGATAGAGGAGTACACCGGGCCTGACCCCGTGCTTGTGGGCAGGCTTCATTCAGAT
ATTGACTCTGGTGATGGGAACATTAAATACATTCTCTCAGGGGAAGGAGCTGGAACCATT
TTTGTGATTGATGACAAATCAGGGAACATTCATGCCACCAAGACGTTGGATCGAGAAGAG
AGAGCCCAGTACACGTTGATGGCTCAGGCGGTGGACAGGGACACCAATCGGCCACTGGAG
CCACCGTCGGAATTCATTGTCAAGGTCCAGGACATTAATGACAACCCTCCGGAGTTCCTG
CACGAGACCTATCATGCCAACGTGCCTGAGAGGTCCAATGTGGGAACGTCAGTAATCCAG
GTGACAGCTTCAGATGCAGATGACCCCACTTATGGAAATAGCGCCAAGTTAGTGTACAGT
ATCCTCGAAGGACAACCCTATTTTTCGGTGGAAGCACAGACAGGTATCATCAGAACAGCC
CTACCCAACATGGACAGGGAGGCCAAGGAGGAGTACCACGTGGTGATCCAGGCCAAGGAC
ATGGGTGGACATATGGGCGGACTCTCAGGGACAACCAAAGTGACGATCACACTGACCGAT
GTCAATGACAACCCACCAAAGTTTCCGCAGAGCGTATACCAGATGTCTGTGTCAGAAGCA
GCCGTCCCTGGGGAGGAAGTAGGAAGAGTGAAAGCTAAAGATCCAGACATTGGAGAAAAT
GGCTTAGTCACATACAATATTGTTGATGGAGATGGTATGGAATCGTTTGAAATCACAACG
GACTATGAAACACAGGAGGGGGTGATAAAGCTGAAAAAGCCTGTAGATTTTGAAACCAAA
AGAGCCTATAGCTTGAAGGTAGAGGCAGCCAACGTGCACATCGACCCGAAGTTTATCAGC
AATGGCCCTTTCAAGGACACTGTGACCGTCAAGATCTCAGTAGAAGATGCTGATGAGCCC
CCTATGTTCTTGGCCCCAAGTTACATCCACGAAGTCCAAGAAAATGCAGCTGCTGGCACC
GTGGTTGGGAGAGTGCATGCCAAAGACCCTGATGCTGCCAACAGCCCGATAAGGTATTCC
ATCGATCGTCACACTGACCTCGACAGATTTTTCACTATTAATCCAGAGGATGGTTTTATT
AAAACTACAAAACCTCTGGATAGAGAGGAAACAGCCTGGCTCAACATCACTGTCTTTGCA
GCAGAAATCCACAATCGGCATCAGGAAGCCAAAGTCCCAGTGGCCATTAGGGTCCTTGAT
GTCAACGATAATGCTCCCAAGTTTGCTGCCCCTTATGAAGGTTTCATCTGTGAGAGTGAT
CAGACCAAGCCACTTTCCAACCAGCCAATTGTTACAATTAGTGCAGATGACAAGGATGAC
ACGGCCAATGGACCAAGATTTATCTTCAGCCTACCCCCTGAAATCATTCACAATCCAAAT
TTCACAGTCAGAGACAACCGAGATAACACAGCAGGCGTGTACGCCCGGCGTGGAGGGTTC
AGTCGGCAGAAGCAGGACTTGTACCTTCTGCCCATAGTGATCAGCGATGGCGGCATCCCG
CCCATGAGTAGCACCAACACCCTCACCATCAAAGTCTGCGGGTGCGACGTGAACGGGGCA
CTGCTCTCCTGCAACGCAGAGGCCTACATTCTGAACGCCGGCCTGAGCACAGGCGCCCTG
ATCGCCATCCTCGCCTGCATCGTCATTCTCCTGGTCATTGTAGTATTGTTTGTGACCCTG
AGAAGGCAAAAGAAAGAACCACTCATTGTCTTTGAGGAAGAAGATGTCCGTGAGAACATC
ATTACTTATGATGATGAAGGGGGTGGGGAAGAAGACACAGAAGCCTTTGATATTGCCACC
CTCCAGAATCCTGATGGTATCAATGGATTTATCCCCCGCAAAGACATCAAACCTGAGTAT
CAGTACATGCCTAGACCTGGGCTCCGGCCAGCGCCCAACAGCGTGGATGTCGATGACTTC
ATCAACACGAGAATACAGGAGGCAGACAATGACCCCACGGCTCCTCCTTATGACTCCATT
CAAATCTACGGTTATGAAGGCAGGGGCTCAGTGGCCGGGTCCCTGAGCTCCCTAGAGTCG
GCCACCACAGATTCAGACTTGGACTATGATTATCTACAGAACTGGGGACCTCGTTTTAAG
AAACTAGCAGATTTGTATGGTTCCAAAGACACTTTTGATGACGATTCTTAA

Chromosome Location

16

Locus

16q21

External Identifiers

Resource	Link
UniProtKB ID	P55287
UniProtKB Entry Name	CAD11_HUMAN
GeneCard ID	CDH11
HGNC ID	HGNC:1750
KEGG ID	hsa:1009
NCBI Gene ID	1009

General References

Not Available

Associated Data

Drug Relations

Drug	Drug group	Pharmacological action?	Type	Actions	Details
Celecoxib	approved, investigational	unknown	target	inhibitor	Details