DNA-directed RNA polymerase subunit beta

BE0010989ProteinMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)rpoB

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. It is acted on by 6 drugs in DrugBank.

Gene name
rpoB
UniProtKB entry
P9WGY9Swiss-Prot
Residues / weight
1,178 residues · 129,864 Da
Also known as
2.7.7.6 · RNA polymerase subunit beta · RNAP subunit beta · Transcriptase subunit beta

Resolves to

Protein
UniProtP9WGY9UniProt nameRPOB_MYCTU
Gene
NCBI Gene888164
Pharmacology
KEGGmtu:Rv0667
Structure
PDB4KBJPDB4KBMPDB5UH5
Drugs

What you can answer from here — as of May 23, 2024

6DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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6Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on DNA-directed RNA polymerase subunit beta, how selective are they, and which programs against it are still in active trials?

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