Presenilin-2

BE0011014ProteinHumansPSEN2

Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10497236, PubMed:10652302, PubMed:16752394, PubMed:27293189, PubMed:36272978). It is acted on by 3 drugs in DrugBank.

Gene name
PSEN2
UniProtKB entry
P49810Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
448 residues · 50,140 Da
Also known as
3.4.23.- · AD3LP · AD4 · AD5 · E5-1

Resolves to

Protein
UniProtP49810UniProt namePSN2_HUMAN
Gene
HGNCHGNC:9509NCBI Gene5664GeneCardsPSEN2
Pharmacology
KEGGhsa:5664
Structure
PDB7Y5XPDB7Y5Z
Drugs

What you can answer from here — as of August 01, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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26GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Presenilin-2, how selective are they, and which programs against it are still in active trials?

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