Lysosomal cobalamin transporter ABCD4

BE0011060ProteinHumansABCD4

Lysosomal membrane protein that transports cobalamin (Vitamin B12) from the lysosomal lumen to the cytosol in an ATP-dependent manner (PubMed:22922874, PubMed:28572511, PubMed:31467407, PubMed:33845046). It is acted on by 1 drug in DrugBank.

Gene name
ABCD4
UniProtKB entry
O14678Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
606 residues · 68,597 Da
Also known as
7.6.2.8 · ATP-binding cassette sub-family D member 4 · P70R · Peroxisomal membrane protein 1-like · Peroxisomal membrane protein 69

Resolves to

Protein
UniProtO14678UniProt nameABCD4_HUMAN
Gene
HGNCHGNC:68NCBI Gene5826GeneCardsABCD4
Pharmacology
KEGGhsa:5826
Structure
PDB6JBJ
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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17GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Lysosomal cobalamin transporter ABCD4, how selective are they, and which programs against it are still in active trials?

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