Eukaryotic elongation factor 2 kinase
Details
- Name
- Eukaryotic elongation factor 2 kinase
- Kind
- protein
- Synonyms
- 2.7.11.20
- Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase
- eEF-2 kinase
- eEF-2K
- Gene Name
- EEF2K
- UniProtKB Entry
- O00418Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0054557|Eukaryotic elongation factor 2 kinase MADEDLIFRLEGVDGGQSPRAGHDGDSDGDSDDEEGYFICPITDDPSSNQNVNSKVNKYY SNLTKSERYSSSGSPANSFHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAV TGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDV YFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYN SNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNL GVRGMALFFYSHACNRICESMGLAPFDLSPRERDAVNQNTKLLQSAKTILRGTEEKCGSP QVRTLSGSRPPLLRPLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFSDLDN MASRDHDHLDNHRESENSGDSGYPSEKRGELDDPEPREHGHSYSNRKYESDEDSLGSSGR VCVEKWNLLNSSRLHLPRASAVALEVQRLNALDLEKKIGKSILGKVHLAMVRYHEGGRFC EKGEEWDQESAVFHLEHAANLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDY LLKAAEAGDRQSMILVARAFDSGQNLSPDRCQDWLEALHWYNTALEMTDCDEGGEYDGMQ DEPRYMMLAREAEMLFTGGYGLEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYQKAEEAW AQMEE
- Number of residues
- 725
- Molecular Weight
- 82143.46
- Theoretical pI
- Not Available
- GO Classification
- Not Available
- General Function
- Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced
- Specific Function
- ATP binding
- Pfam Domain Function
- Alpha_kinase (PF02816)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
- Not Available
- Chromosome Location
- 16
- Locus
- 16p12.2
- External Identifiers
Resource Link UniProtKB ID O00418 UniProtKB Entry Name EF2K_HUMAN GeneCard ID EEF2K HGNC ID HGNC:24615 PDB ID(s) 5J8H, 5KS5, 6NX4, 7SHQ, 8FNY, 8FO6, 8GM4, 8GM5 KEGG ID hsa:29904 IUPHAR/Guide To Pharmacology ID 2014 NCBI Gene ID 29904 - General References
- Not Available