Eukaryotic elongation factor 2 kinase

BE0011325ProteinHumansEEF2K

Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. It is acted on by 3 drugs in DrugBank.

Gene name
EEF2K
UniProtKB entry
O00418Swiss-Prot
Residues / weight
725 residues · 82,143 Da
Also known as
2.7.11.20 · Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase · eEF-2 kinase · eEF-2K

Resolves to

Protein
UniProtO00418UniProt nameEF2K_HUMAN
Gene
HGNCHGNC:24615NCBI Gene29904GeneCardsEEF2K
Pharmacology
IUPHAR/GtoPdb2014KEGGhsa:29904
Structure
PDB5J8HPDB5KS5PDB6NX4
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Eukaryotic elongation factor 2 kinase, how selective are they, and which programs against it are still in active trials?

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