Cefatrizine

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
Cefatrizine
DrugBank Accession Number
DB13266
Background

Not Available

Type
Small Molecule
Groups
Experimental
Structure
Weight
Average: 462.5
Monoisotopic: 462.078010052
Chemical Formula
C18H18N6O5S2
Synonyms
  • cefatrizina
  • céfatrizine
  • Cefatrizine
  • cefatrizinum
External IDs
  • antibiotic BL-S 640
  • BL-S 640
  • BL-S640
  • BLS 640
  • S-640P
  • SKF 60771

Pharmacology

Indication

Not Available

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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbacavirCefatrizine may decrease the excretion rate of Abacavir which could result in a higher serum level.
AbciximabThe therapeutic efficacy of Abciximab can be decreased when used in combination with Cefatrizine.
AceclofenacThe risk or severity of nephrotoxicity can be increased when Aceclofenac is combined with Cefatrizine.
AcemetacinThe risk or severity of nephrotoxicity can be increased when Cefatrizine is combined with Acemetacin.
AcenocoumarolThe risk or severity of bleeding can be increased when Cefatrizine is combined with Acenocoumarol.
Food Interactions
Not Available

Products

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Product Ingredients
IngredientUNIICASInChI Key
Cefatrizine propylene glycolate3731IA5GI964217-62-5CKOIKOHDEYTLFR-PFBPGKLMSA-N

Categories

ATC Codes
J01DB07 — Cefatrizine
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as cephalosporins. These are compounds containing a 1,2-thiazine fused to a 2-azetidinone to for a oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid moiety or a derivative thereof.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Lactams
Sub Class
Beta lactams
Direct Parent
Cephalosporins
Alternative Parents
N-acyl-alpha amino acids and derivatives / Alpha amino acid amides / Phenylacetamides / 1-hydroxy-2-unsubstituted benzenoids / Alkylarylthioethers / Aralkylamines / 1,3-thiazines / Triazoles / Tertiary carboxylic acid amides / Heteroaromatic compounds
show 14 more
Substituents
1,2,3-triazole / 1-hydroxy-2-unsubstituted benzenoid / Alkylarylthioether / Alpha-amino acid amide / Alpha-amino acid or derivatives / Amine / Amino acid / Amino acid or derivatives / Aralkylamine / Aromatic heteropolycyclic compound
show 33 more
Molecular Framework
Aromatic heteropolycyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
8P4W949T8K
CAS number
51627-14-6
InChI Key
UOCJDOLVGGIYIQ-PBFPGSCMSA-N
InChI
InChI=1S/C18H18N6O5S2/c19-12(8-1-3-10(25)4-2-8)15(26)21-13-16(27)24-14(18(28)29)9(7-31-17(13)24)6-30-11-5-20-23-22-11/h1-5,12-13,17,25H,6-7,19H2,(H,21,26)(H,28,29)(H,20,22,23)/t12-,13-,17-/m1/s1
IUPAC Name
(6R,7R)-7-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-8-oxo-3-[(1H-1,2,3-triazol-4-ylsulfanyl)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
SMILES
[H][C@@]1(NC(=O)[C@H](N)C2=CC=C(O)C=C2)C(=O)N2C(C(O)=O)=C(CSC3=CNN=N3)CS[C@]12[H]

References

General References
Not Available
KEGG Drug
D02406
ChemSpider
4918615
RxNav
2179
ChEBI
131730
ChEMBL
CHEMBL1095284
ZINC
ZINC000003830404
Wikipedia
Cefatrizine

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Capsule
Tablet
Tablet, coated
Granule, for suspensionOral
Capsule500 MG
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.149 mg/mLALOGPS
logP-0.28ALOGPS
logP-2.2Chemaxon
logS-3.5ALOGPS
pKa (Strongest Acidic)2.92Chemaxon
pKa (Strongest Basic)7.22Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count8Chemaxon
Hydrogen Donor Count5Chemaxon
Polar Surface Area174.53 Å2Chemaxon
Rotatable Bond Count7Chemaxon
Refractivity115.69 m3·mol-1Chemaxon
Polarizability42.34 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0002-0040900000-3d03939b82a085d58ed4
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-08fs-4597700000-3f81ac983a25fa02cfab
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-08mi-0954600000-2652692219cc81fd0111
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-00ls-9035600000-d87a000f9c03b350915b
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-00e9-0941300000-6cf34a5e7230b9a2f145
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-00di-6900100000-989be08cb9afb372656e
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-218.6320634
predicted
DarkChem Lite v0.1.0
[M-H]-200.40317
predicted
DeepCCS 1.0 (2019)
[M+H]+217.6820634
predicted
DarkChem Lite v0.1.0
[M+H]+202.2989
predicted
DeepCCS 1.0 (2019)
[M+Na]+208.14873
predicted
DeepCCS 1.0 (2019)

Drug created at June 23, 2017 20:38 / Updated at February 21, 2021 18:54