Deoxyribonuclease-2-alpha

BE0011359ProteinHumansDNASE2

Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. It is acted on by 1 drug in DrugBank.

Gene name
DNASE2
UniProtKB entry
O00115Swiss-Prot
Cellular location
Lysosome
Residues / weight
360 residues · 39,581 Da
Also known as
3.1.22.1 · Acid DNase · Deoxyribonuclease II alpha · DNase II alpha · DNASE2A

Resolves to

Protein
UniProtO00115UniProt nameDNS2A_HUMAN
Gene
HGNCHGNC:2960NCBI Gene1777GeneCardsDNASE2
Pharmacology
KEGGhsa:1777
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Deoxyribonuclease-2-alpha, how selective are they, and which programs against it are still in active trials?

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