Sodium ascorbate

Identification

Brand Names
Irospan 24/6 Kit, Mega-C, Moviprep, Plenvu, Tandem Plus
Generic Name
Sodium ascorbate
DrugBank Accession Number
DB14482
Background

Not Available

Type
Small Molecule
Groups
Approved, Nutraceutical
Structure
Thumb
Weight
Average: 198.106
Monoisotopic: 198.01403223
Chemical Formula
C6H7NaO6
Synonyms
  • Ascorbato sódico
  • Ascorbic acid sodium salt
  • L-Ascorbic acid sodium salt
  • L-Ascorbic acid, monosodium salt
  • Monosodium L-ascorbate
  • Sodium ascorbate
  • sodium L-ascorbate
  • Vitamin C sodium
  • Vitamin C, sodium salt

Pharmacology

Indication

Not Available

Pharmacology
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Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Medicalerrors
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcetazolamideThe risk or severity of adverse effects can be increased when Acetazolamide is combined with Sodium ascorbate.
AclidiniumThe therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Aclidinium.
AlfentanilThe therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Alfentanil.
AlloinThe risk or severity of adverse effects can be increased when Sodium ascorbate is combined with Alloin.
AlmasilateThe therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Almasilate.
Aluminium phosphateThe therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Aluminium phosphate.
Aluminum hydroxideThe therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Aluminum hydroxide.
AmantadineThe therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Amantadine.
AmilorideThe risk or severity of adverse effects can be increased when Amiloride is combined with Sodium ascorbate.
AmiodaroneThe therapeutic efficacy of Sodium ascorbate can be decreased when used in combination with Amiodarone.
Interactions
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Food Interactions
No interactions found.

Products

Products
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Active Moieties
NameKindUNIICASInChI Key
Ascorbic acidunknownPQ6CK8PD0R50-81-7CIWBSHSKHKDKBQ-JLAZNSOCSA-N
Sodium cationionicLYR4M0NH3717341-25-2FKNQFGJONOIPTF-UHFFFAOYSA-N
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Mega-C-sodium Inj 250mg/mlSolution250 mg / mLIntravenousKripps Pharmacy Ltd.1981-12-31Not applicableCanada flag
Vitamin CLiquid250 mg / mLIntramuscular; IntravenousSandoz Canada Incorporated1989-12-31Not applicableCanada flag
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
C Wafer 500 Chewable 500mgWafer500 mg / wafOralNu Life Nutrition Ltd.1986-12-312000-05-23Canada flag
Natural Fruit Chew C 250mg Tangy Orange FlavourTablet250 mgOralNatural Factors Nutritional Products Ltd.2001-01-012009-09-28Canada flag
Sodium Ascor Crystal 888.8mg/gm USPPowder888.8 mg / gOralVita Health Products Inc1996-10-112002-07-31Canada flag
Tgi Tab 50mgTablet50 mg / tabOralSeroyal International Inc.1980-12-311996-09-10Canada flag
Vitamin C 60mgTablet60 mgOralWn Pharmaceuticals Ltd.1999-04-092008-07-17Canada flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Animal Shaped Chew Vit C Tab 250mgSodium ascorbate (159 mg) + Ascorbic acid (110 mg)TabletOralHall Laboratories, Ltd.1982-12-312003-09-11Canada flag
AppedrineSodium ascorbate (10 mg) + Benzocaine (3 mg) + Ferrous fumarate (3.33 mg) + Nicotinamide (3.33 mg) + Riboflavin (.4 mg) + Thiamine hydrochloride (.33 mg) + Vitamin A (1333 unit) + Vitamin D (133 unit)TabletOralChattem, Inc.1975-12-312004-07-08Canada flag
Ascorbex 500 TabSodium ascorbate (337.5 mg) + Ascorbic acid (200 mg)TabletOralSantÉ Naturelle (Ag) LtÉe1988-12-312004-08-05Canada flag
Bugs Bunny and Friends Multiple VitaminsSodium ascorbate (50 mg) + Cyanocobalamin (3 mcg) + Folic acid (0.1 mg) + Nicotinamide (15 mg) + Pyridoxine hydrochloride (1 mg) + Riboflavin (1.5 mg) + Thiamine mononitrate (1.5 mg) + Vitamin A (5000 unit) + Vitamin D (400 unit)TabletOralBayer Inc Consumer Care1996-12-312004-04-15Canada flag
Bugs Bunny Chew Multi Vit Plus IronSodium ascorbate (50 mg / tab) + Cyanocobalamin (3 mcg / tab) + Ferrous fumarate (12 mg / tab) + Folic acid (.1 mg / tab) + Nicotinamide (15 mg / tab) + Pyridoxine hydrochloride (1 mg / tab) + Riboflavin (1.5 mg / tab) + Thiamine mononitrate (1.5 mg / tab) + Vitamin A acetate (5000 unit / tab) + Vitamin D (400 unit / tab)TabletOralMiles Inc. Pharmaceutical Division1983-12-311996-09-09Canada flag
Champs Vitamin C Chewable 100mg (Natural Orange Flavour)Sodium ascorbate (40 mg) + Ascorbic acid (65 mg)Tablet, chewableOralDUOPHARMA MANUFACTURING (BANGI) SDN BHD2020-09-08Not applicableMalaysia flag
Champs Vitamin C Chewable 100mg (Strawberry)Sodium ascorbate (40 mg) + Ascorbic acid (65 mg)Tablet, chewableOralDUOPHARMA MANUFACTURING (BANGI) SDN BHD2020-09-08Not applicableMalaysia flag
Chewable Multiple Vitamins for ChildrenSodium ascorbate (50 mg / tab) + Cyanocobalamin (3 mcg / tab) + Folic acid (.1 mg / tab) + Nicotinamide (15 mg / tab) + Pyridoxine hydrochloride (1 mg / tab) + Riboflavin (1.5 mg / tab) + Thiamine mononitrate (1.5 mg / tab) + Vitamin A acetate (5000 unit / tab) + Vitamin D (400 unit / tab)TabletOralRandle Pharmaceutical Inc.1996-09-191999-09-03Canada flag
Chewable MultivitaminsSodium ascorbate (50 mg) + Cholecalciferol (400 unit) + Cyanocobalamin (3 mcg) + Folic acid (0.1 mg) + Nicotinamide (15 mg) + Pyridoxine hydrochloride (1 mg) + Riboflavin (1.5 mg) + Thiamine mononitrate (1.5 mg) + Vitamin A (5000 unit)TabletOralWn Pharmaceuticals Ltd.2002-05-312008-07-17Canada flag
Chewable Multivitamins Plus IronSodium ascorbate (50 mg) + Cholecalciferol (400 unit) + Cyanocobalamin (3 mcg) + Ferrous fumarate (4 mg) + Folic acid (0.1 mg) + Nicotinamide (15 mg) + Pyridoxine hydrochloride (1 mg) + Riboflavin (1.5 mg) + Thiamine mononitrate (1.5 mg) + Vitamin A (5000 unit)TabletOralWn Pharmaceuticals Ltd.2002-05-312007-08-07Canada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
CentratexSodium ascorbate (200 mg/1) + Cupric sulfate (0.8 mg/1) + Cyanocobalamin (15 ug/1) + Folic acid (1 mg/1) + Iron (106 mg/1) + Magnesium sulfate (6.9 mg/1) + Manganese sulfate (1.3 mg/1) + Nicotinamide (30 mg/1) + Calcium pantothenate (10 mg/1) + Pyridoxine hydrochloride (5 mg/1) + Riboflavin (6 mg/1) + Thiamine mononitrate (10 mg/1) + Zinc sulfate, unspecified form (18.2 mg/1)CapsuleOralCenturion Labs, LLC2009-06-14Not applicableUS flag
Irospan 24/6Sodium ascorbate (100 mg/1) + Sodium ascorbate (100 mg/1) + Biotin (300 ug/1) + Biotin (300 ug/1) + Calcium carbonate (100 mg/1) + Cyanocobalamin (10 ug/1) + Cyanocobalamin (10 ug/1) + Ferrous bisglycinate (65 mg/1) + Folic acid (1 mg/1) + Folic acid (1 mg/1) + Calcium formate (155 mg/1) + Iron Dextran (65 mg/1) + Niacin (25 mg/1) + Niacin (25 mg/1) + Calcium pantothenate (300 ug/1) + Calcium pantothenate (7 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Riboflavin sodium (5 mg/1) + Riboflavin (5 mg/1) + Succinic acid (150 mg/1) + Thiamine hydrochloride (5 mg/1) + Thiamine hydrochloride (5 mg/1)OralWOMENS CHOICE PHARMACEUTICALS LLC2011-04-15Not applicableUS flag
Irospan 24/6Sodium ascorbate (100 mg/1) + Sodium ascorbate (100 mg/1) + Biotin (300 ug/1) + Biotin (300 ug/1) + Calcium carbonate (100 mg/1) + Cyanocobalamin (10 ug/1) + Cyanocobalamin (10 ug/1) + Ferrous bisglycinate (65 mg/1) + Folic acid (1 mg/1) + Folic acid (1 mg/1) + Calcium formate (155 mg/1) + Iron Dextran (65 mg/1) + Niacin (25 mg/1) + Niacin (25 mg/1) + Calcium pantothenate (300 ug/1) + Calcium pantothenate (7 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Pyridoxine hydrochloride (30 mg/1) + Riboflavin sodium (5 mg/1) + Riboflavin (5 mg/1) + Succinic acid (150 mg/1) + Thiamine hydrochloride (5 mg/1) + Thiamine hydrochloride (5 mg/1)OralWOMENS CHOICE PHARMACEUTICALS LLC2011-04-15Not applicableUS flag
Multi Vitamin with FluorideSodium ascorbate (36 mg/1) + Ascorbic acid (24 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Nicotinamide (13.5 mg/1) + Pyridoxine hydrochloride (1.05 mg/1) + Riboflavin (1.2 mg/1) + Sodium fluoride (0.5 mg/1) + Thiamine mononitrate (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1)Tablet, chewableOralA S Medication Solutions2009-10-09Not applicableUS flag
Multi Vitamin with FluorideSodium ascorbate (36 mg/1) + Ascorbic acid (24 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Nicotinamide (13.5 mg/1) + Pyridoxine hydrochloride (1.05 mg/1) + Riboflavin (1.2 mg/1) + Sodium fluoride (0.5 mg/1) + Thiamine mononitrate (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1)Tablet, chewableOralPhysicians Total Care, Inc.2003-09-082013-01-15US flag
Multi Vitamin with FluorideSodium ascorbate (36 mg/1) + Ascorbic acid (24 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Nicotinamide (13.5 mg/1) + Pyridoxine hydrochloride (1.05 mg/1) + Riboflavin (1.2 mg/1) + Sodium fluoride (0.25 mg/1) + Thiamine mononitrate (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1)Tablet, chewableOralQualitest2009-10-092014-08-31US flag
Multi Vitamin with FluorideSodium ascorbate (36 mg/1) + Ascorbic acid (24 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Nicotinamide (13.5 mg/1) + Pyridoxine hydrochloride (1.05 mg/1) + Riboflavin (1.2 mg/1) + Sodium fluoride (0.25 mg/1) + Thiamine mononitrate (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1)Tablet, chewableOralPhysicians Total Care, Inc.2003-09-052013-01-15US flag
Multi Vitamin with FluorideSodium ascorbate (36 mg/1) + Ascorbic acid (24 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Nicotinamide (13.5 mg/1) + Pyridoxine hydrochloride (1.05 mg/1) + Riboflavin (1.2 mg/1) + Sodium fluoride (1 mg/1) + Thiamine mononitrate (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1)Tablet, chewableOralQualitest2009-10-092014-12-31US flag
Multi Vitamin with FluorideSodium ascorbate (36 mg/1) + Ascorbic acid (24 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Nicotinamide (13.5 mg/1) + Pyridoxine hydrochloride (1.05 mg/1) + Riboflavin (1.2 mg/1) + Sodium fluoride (1 mg/1) + Thiamine mononitrate (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1)Tablet, chewableOralPhysicians Total Care, Inc.2003-06-042013-01-15US flag
Multi Vitamin with FluorideSodium ascorbate (36 mg/1) + Ascorbic acid (24 mg/1) + Cholecalciferol (400 [iU]/1) + Cyanocobalamin (4.5 ug/1) + DL-alpha tocopheryl acetate (15 [iU]/1) + Folic acid (0.3 mg/1) + Nicotinamide (13.5 mg/1) + Pyridoxine hydrochloride (1.05 mg/1) + Riboflavin (1.2 mg/1) + Sodium fluoride (0.5 mg/1) + Thiamine mononitrate (1.05 mg/1) + Vitamin A acetate (2500 [iU]/1)Tablet, chewableOralQualitest2009-10-092014-12-31US flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as butenolides. These are dihydrofurans with a carbonyl group at the C2 carbon atom.
Kingdom
Organic compounds
Super Class
Organoheterocyclic compounds
Class
Dihydrofurans
Sub Class
Furanones
Direct Parent
Butenolides
Alternative Parents
Vinylogous acids / Enoate esters / Secondary alcohols / Lactones / 1,2-diols / Oxacyclic compounds / Monocarboxylic acids and derivatives / Primary alcohols / Organic zwitterions / Organic sodium salts
show 3 more
Substituents
1,2-diol / 2-furanone / Alcohol / Aliphatic heteromonocyclic compound / Alpha,beta-unsaturated carboxylic ester / Carbonyl group / Carboxylic acid derivative / Carboxylic acid ester / Enoate ester / Hydrocarbon derivative
show 13 more
Molecular Framework
Aliphatic heteromonocyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
S033EH8359
CAS number
134-03-2
InChI Key
PPASLZSBLFJQEF-RXSVEWSESA-M
InChI
InChI=1S/C6H8O6.Na/c7-1-2(8)5-3(9)4(10)6(11)12-5;/h2,5,7-10H,1H2;/q;+1/p-1/t2-,5+;/m0./s1
IUPAC Name
sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate
SMILES
[Na+].[H][C@@]1(OC(=O)C(O)=C1[O-])[C@@H](O)CO

References

General References
Not Available
KEGG Drug
D05853
ChemSpider
16736174
ChEBI
113451
ChEMBL
CHEMBL591665
PharmGKB
PA166163262
Wikipedia
Sodium_ascorbate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedNot AvailableColonoscopy1
4CompletedBasic ScienceFunctional Constipation / Irritable Bowel Syndrome Characterized by Constipation1
4CompletedDiagnosticColon Adenomas / Colon Lesion / Colon Polyps1
4CompletedScreeningColorectal, Cancer1
4CompletedTreatmentBowel Preparation for Colonoscopy1
4CompletedTreatmentColon Cleansing for Colonoscopy1
4CompletedTreatmentColonoscopy1
4CompletedTreatmentColorectal Cleansing Prior Operation1
4CompletedTreatmentGastrointestinal Diseases1
4Not Yet RecruitingTreatmentColon Diseases1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionIntravenous10 g
TabletTransmucosal
WaferOral500 mg / waf
TabletOral
Tablet, orally disintegratingTransmucosal
Capsule, delayed releaseOral
Capsule, liquid filledOral560 mg
SolutionIntravenous250 mg / mL
KitOral
SolutionOral
Powder, for solutionOral
Capsule, liquid filledOral
Tablet, chewableOral
Tablet, film coated
TabletOral250 mg
Tablet, film coatedOral
KitIntravenous
LiquidOral
PowderOral
Capsule, gelatin coatedOral
Tablet, effervescentOral
PowderOral888.8 mg / g
Injection, solutionIntravenous
Injection, powder, for solutionIntravenous
Injection, powder, lyophilized, for solutionIntravenous
CapsuleOral
TabletOral50 mg / tab
Tablet, coatedOral
LiquidIntramuscular; Intravenous250 mg / mL
TabletOral60 mg
Tablet, chewableBuccal
LozengeOral
Prices
Not Available
Patents
Patent NumberPediatric ExtensionApprovedExpires (estimated)Region
US7169381No2007-01-302024-09-01US flag
US7658914No2010-02-092024-09-01US flag
US9326969No2016-05-032033-09-10US flag
US9592252No2017-03-142032-08-11US flag
US9707297No2017-07-182033-09-10US flag
US8999313No2015-04-072033-09-10US flag
US10016504No2018-07-102033-09-10US flag
US10646512No2012-03-252032-03-25US flag
US10792306No2012-03-092032-03-09US flag
US10780112No2012-03-092032-03-09US flag
US10918723No2013-09-102033-09-10US flag

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility625.0 mg/mLALOGPS
logP-1.4ALOGPS
logP-1.9ChemAxon
logS0.5ALOGPS
pKa (Strongest Acidic)4.36ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area110.05 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity47.58 m3·mol-1ChemAxon
Polarizability14.51 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on July 06, 2018 22:02 / Updated on July 24, 2021 14:58