Ubiquitin C-terminal hydrolase PSMD14

BE0011425ProteinHumansPSMD14

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. It is acted on by 1 drug in DrugBank.

Gene name
PSMD14
UniProtKB entry
O00487Swiss-Prot
Residues / weight
310 residues · 34,577 Da
Also known as
26S proteasome non-ATPase regulatory subunit 14 · 26S proteasome regulatory subunit RPN11 · 26S proteasome-associated PAD1 homolog 1 · 3.4.19.12 · POH1

Resolves to

Protein
UniProtO00487UniProt namePSDE_HUMAN
Gene
HGNCHGNC:16889NCBI Gene10213GeneCardsPSMD14
Pharmacology
KEGGhsa:10213
Structure
PDB5GJQPDB5GJRPDB5L4K
Drugs

What you can answer from here — as of June 05, 2026

1DrugApproved to experimental, with action, bond type and pharmacological action
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30GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Ubiquitin C-terminal hydrolase PSMD14, how selective are they, and which programs against it are still in active trials?

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