N-glycosylase/DNA lyase

BE0011684ProteinHumansOGG1

DNA repair enzyme that incises DNA at 8-oxoG residues. It is acted on by 1 drug in DrugBank.

Gene name
OGG1
UniProtKB entry
O15527Swiss-Prot
Cellular location
Nucleus, nucleoplasm
Residues / weight
345 residues · 38,782 Da
Also known as
MMH · MUTM · OGH1

Resolves to

Protein
UniProtO15527UniProt nameOGG1_HUMAN
Gene
HGNCHGNC:8125NCBI Gene4968GeneCardsOGG1
Pharmacology
KEGGhsa:4968
Structure
PDB1EBMPDB1FN7PDB1HU0
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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31GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on N-glycosylase/DNA lyase, and which indications are they being tested in?

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