Protein phosphatase 1 regulatory subunit 15A

BE0011888ProteinHumansPPP1R15A

Recruits the serine/threonine-protein phosphatase PPP1CA to prevents excessive phosphorylation of the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress (PubMed:26095357, PubMed:26742780). It is acted on by 1 drug in DrugBank.

Gene name
PPP1R15A
UniProtKB entry
O75807Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
674 residues · 73,477 Da
Also known as
GADD34 · Growth arrest and DNA damage-inducible protein GADD34 · Myeloid differentiation primary response protein MyD116 homolog

Resolves to

Protein
UniProtO75807UniProt namePR15A_HUMAN
Gene
HGNCHGNC:14375NCBI Gene23645GeneCardsPPP1R15A
Pharmacology
KEGGhsa:23645
Structure
PDB4XPNPDB7NXVPDB7NZM
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Protein phosphatase 1 regulatory subunit 15A, and which indications are they being tested in?

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