Pantetheinase

BE0012284ProteinHumansVNN1

Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. It is acted on by 1 drug in DrugBank.

Gene name
VNN1
UniProtKB entry
O95497Swiss-Prot
Cellular location
Cell membrane
Residues / weight
513 residues · 57,011 Da
Also known as
3.5.1.92 · Pantetheine hydrolase · Tiff66 · Vanin-1 · Vascular non-inflammatory molecule 1

Resolves to

Protein
UniProtO95497UniProt nameVNN1_HUMAN
Gene
HGNCHGNC:12705NCBI Gene8876GeneCardsVNN1
Pharmacology
IUPHAR/GtoPdb3063KEGGhsa:8876
Structure
PDB4CYFPDB4CYGPDB4CYY
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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15GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on Pantetheinase, how selective are they, and which programs against it are still in active trials?

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