DNA-directed RNA polymerase I subunit RPA1

BE0012326ProteinHumansPOLR1A

Catalytic core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. It is acted on by 2 drugs in DrugBank.

Gene name
POLR1A
UniProtKB entry
O95602Swiss-Prot
Cellular location
Nucleus, nucleolus
Residues / weight
1,720 residues · 194,810 Da
Also known as
2.7.7.6 · A190 · DNA-directed RNA polymerase I largest subunit · DNA-directed RNA polymerase I subunit A · RNA polymerase I 194 kDa subunit

Resolves to

Protein
UniProtO95602UniProt nameRPA1_HUMAN
Gene
HGNCHGNC:17264NCBI Gene25885GeneCardsPOLR1A
Pharmacology
KEGGhsa:25885
Structure
PDB7OB9PDB7OBAPDB7OBB
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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16GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on DNA-directed RNA polymerase I subunit RPA1, and which indications are they being tested in?

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