Poly [ADP-ribose] polymerase tankyrase-1

BE0012352ProteinHumansTNKS

Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379, PubMed:28619731). It is acted on by 3 drugs in DrugBank.

Gene name
TNKS
UniProtKB entry
O95271Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,327 residues · 142,038 Da
Also known as
2.4.2.30 · ADP-ribosyltransferase diphtheria toxin-like 5 · ARTD5 · PARP5A · PARPL

Resolves to

Protein
UniProtO95271UniProt nameTNKS1_HUMAN
Gene
HGNCHGNC:11941NCBI Gene8658GeneCardsTNKS
Pharmacology
IUPHAR/GtoPdb3108KEGGhsa:8658
Structure
PDB2RF5PDB3UDDPDB3UH2
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Poly [ADP-ribose] polymerase tankyrase-1, and which indications are they being tested in?

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