Nesuparib

DB18110InvestigationalSmall molecule

Nesuparib: Overview.

Mechanism: Pharmacologically active on Poly [ADP-ribose] polymerase 1, Poly [ADP-ribose] polymerase 2, and Poly [ADP-ribose] polymerase tankyrase-1
Curator reviewed
Formula / weight: C₂₃H₂₄N₆O · 400.486 g/mol (avg)
Also known as: 6-(4-((5-oxo-1,2,3,4,5,6-hexahydrobenzo(h)(1,6)naphthyridin-8-yl)methyl)piperazin-1-yl)nicotinonitrile
Code names: JPI-547

Resolves to

Compound

Structure

InChIKeyGRPXLKXGJAGYSD-UHFFFAOYSA-NSMILESO=C1NC2=CC(CN3CCN(CC3)C3=CC=C(C=N3)C#N)=CC=C2C2=C1CCCN2

Targets

What you can answer from here — as of August 30, 2026

4Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

7Clinical trialsPhase, status and sponsor resolved per trial

20+ReferencesStructured and connected to the statements they support

Which drugs share a target with Nesuparib, and which of those have an active Phase 3 trial?

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