Band 3 anion transport protein

BE0012390ProteinHumansSLC4A1

Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein (PubMed:10926824, PubMed:14734552, PubMed:1538405, PubMed:16227998, PubMed:20151848, PubMed:24121512, PubMed:28387307, PubMed:35835865). It is acted on by 4 drugs in DrugBank.

Gene name
SLC4A1
UniProtKB entry
P02730Swiss-Prot
Cellular location
Cell membrane
Residues / weight
911 residues · 101,791 Da
Also known as
AE 1 · AE1 · Anion exchange protein 1 · Anion exchanger 1 · DI

Resolves to

Protein
UniProtP02730UniProt nameB3AT_HUMAN
Gene
HGNCHGNC:11027NCBI Gene6521GeneCardsSLC4A1
Pharmacology
KEGGhsa:6521
Structure
PDB1BH7PDB1BNXPDB1BTQ
Drugs

What you can answer from here — as of September 03, 2024

4DrugsApproved to experimental, with action, bond type and pharmacological action
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24GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Band 3 anion transport protein, how selective are they, and which programs against it are still in active trials?

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