ATP-dependent 6-phosphofructokinase, muscle type

BE0012586ProteinHumansPFKM

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. It is acted on by 1 drug in DrugBank.

Gene name
PFKM
UniProtKB entry
P08237Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
780 residues · 85,182 Da
Also known as
2.7.1.11 · 6-phosphofructokinase type A · ATP-PFK · PFK-A · PFK-M

Resolves to

Protein
UniProtP08237UniProt namePFKAM_HUMAN
Gene
HGNCHGNC:8877NCBI Gene5213GeneCardsPFKM
Pharmacology
KEGGhsa:5213
Structure
PDB4OMT
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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19GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on ATP-dependent 6-phosphofructokinase, muscle type, and which indications are they being tested in?

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