Calpain-2 catalytic subunit
Details
- Name
- Calpain-2 catalytic subunit
- Kind
- protein
- Synonyms
- 3.4.22.53
- Calcium-activated neutral proteinase 2
- Calpain large polypeptide L2
- Calpain M-type
- Calpain-2 large subunit
- CANP 2
- CANPL2
- M-calpain
- Millimolar-calpain
- Gene Name
- CAPN2
- UniProtKB Entry
- P17655Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0055894|Calpain-2 catalytic subunit MAGIAAKLAKDREAAEGLGSHDRAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGF KELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEI LARVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSAL LEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGC SIDITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDN CPSWNTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTK MDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQR KMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPG EYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQ LAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYIL WTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFD NFVRCLVRLETLFKIFKQLDPENTGTIELDLISWLCFSVL
- Number of residues
- 700
- Molecular Weight
- 79994.545
- Theoretical pI
- Not Available
- GO Classification
- Not Available
- General Function
- Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity)
- Specific Function
- calcium ion binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
- Not Available
- Chromosome Location
- 1
- Locus
- 1q41
- External Identifiers
Resource Link UniProtKB ID P17655 UniProtKB Entry Name CAN2_HUMAN GeneCard ID CAPN2 HGNC ID HGNC:1479 PDB ID(s) 1KFU, 1KFX, 2NQA KEGG ID hsa:824 IUPHAR/Guide To Pharmacology ID 2337 NCBI Gene ID 824 - General References
- Not Available
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Aloxistatin investigational yes target inhibitor Details Bithionol approved, withdrawn yes target inhibitor Details