Calpain-2 catalytic subunit

BE0012693ProteinHumansCAPN2

Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. It is acted on by 3 drugs in DrugBank.

Gene name
CAPN2
UniProtKB entry
P17655Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
700 residues · 79,995 Da
Also known as
3.4.22.53 · Calcium-activated neutral proteinase 2 · Calpain large polypeptide L2 · Calpain M-type · Calpain-2 large subunit

Resolves to

Protein
UniProtP17655UniProt nameCAN2_HUMAN
Gene
HGNCHGNC:1479NCBI Gene824GeneCardsCAPN2
Pharmacology
IUPHAR/GtoPdb2337KEGGhsa:824
Structure
PDB1KFUPDB1KFXPDB2NQA
Drugs

What you can answer from here — as of September 03, 2024

3DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Calpain-2 catalytic subunit, how selective are they, and which programs against it are still in active trials?

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