Tyrosine-protein phosphatase non-receptor type 2

BE0012706ProteinHumansPTPN2

Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. It is acted on by 1 drug in DrugBank.

Gene name
PTPN2
UniProtKB entry
P17706Swiss-Prot
Cellular location
Endoplasmic reticulum
Residues / weight
415 residues · 48,473 Da
Also known as
3.1.3.48 · PTPT · T-cell protein-tyrosine phosphatase · TCPTP

Resolves to

Protein
UniProtP17706UniProt namePTN2_HUMAN
Gene
HGNCHGNC:9650NCBI Gene5771GeneCardsPTPN2
Pharmacology
IUPHAR/GtoPdb3255KEGGhsa:5771
Structure
PDB1L8KPDB6ZZ4PDB7F5N
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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42GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Tyrosine-protein phosphatase non-receptor type 2, and which indications are they being tested in?

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