Osunprotafib

DB21547InvestigationalSmall molecule

Osunprotafib is a small molecule drug. The usage of the INN stem '-protafib' in the name indicates that Osunprotafib is a human protein tyrosine phosphatase (HPTP) inhibitor. Osunprotafib is under... Osunprotafib is under investigation in clinical trial NCT04777994 (Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors).

Mechanism: Pharmacologically active on Tyrosine-protein phosphatase non-receptor type 1 and Tyrosine-protein phosphatase non-receptor type 2
Curator reviewed
Formula / weight: C₁₇H₂₄FN₃O₄S · 385.45 g/mol (avg)
Code names: ABBV-CLS-484

Resolves to

Compound

UNII82TTG6WR6BCAS2489404-97-7ChEMBLCHEMBL5095164

Structure

InChIKeyDVFCRTGTEXUFIN-GFCCVEGCSA-NSMILESCC(C)CCN[C@@H]1CCC2=C(C1)C(F)=C(N1CC(=O)NS1(=O)=O)C(O)=C2

Targets

P18031PTPN1P17706PTPN2

What you can answer from here — as of September 12, 2026

2Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

2Clinical trialsPhase, status and sponsor resolved per trial

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Osunprotafib, and which of those have an active Phase 3 trial?

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