Xaa-Pro dipeptidase

BE0012715ProteinHumansPEPD

Dipeptidase that catalyzes the hydrolysis of dipeptides with a prolyl (Xaa-Pro) or hydroxyprolyl residue in the C-terminal position (PubMed:17081196, PubMed:35165443). It is acted on by 1 drug in DrugBank.

Gene name: PEPD
UniProtKB entry: P12955Swiss-Prot
Residues / weight: 493 residues · 54,548 Da
Also known as: 3.4.13.9 · Imidodipeptidase · Peptidase D · PRD · Prolidase

Resolves to

Protein

UniProtP12955UniProt namePEPD_HUMAN

Gene

HGNCHGNC:8840NCBI Gene5184GeneCardsPEPD

Pharmacology

KEGGhsa:5184

Structure

PDB2IW2PDB2OKNPDB5M4G

Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action

8GO termsFunction, process and component, as structured annotations

2Pfam domainsDomain architecture mapped to Pfam families and clans

5+ReferencesStructured and connected to the statements they support

Which approved drugs act on Xaa-Pro dipeptidase, how selective are they, and which programs against it are still in active trials?

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