Polyunsaturated fatty acid lipoxygenase ALOX12

BE0012732ProteinHumansALOX12

Catalyzes the regio and stereo-specific incorporation of molecular oxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:17493578, PubMed:18311922, PubMed:1851637, PubMed:32404334, PubMed:8319693, PubMed:8500694). It is acted on by 4 drugs in DrugBank.

Gene name
ALOX12
UniProtKB entry
P18054Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
663 residues · 75,693 Da
Also known as
1.13.11.- · 12LO · 12S-lipoxygenase · 12S-LOX · Arachidonate (12S)-lipoxygenase

Resolves to

Protein
UniProtP18054UniProt nameLOX12_HUMAN
Gene
HGNCHGNC:429NCBI Gene239GeneCardsALOX12
Pharmacology
IUPHAR/GtoPdb1387KEGGhsa:239
Structure
PDB3D3LPDB8GHBPDB8GHC
Drugs

What you can answer from here — as of September 03, 2024

4DrugsApproved to experimental, with action, bond type and pharmacological action
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Polyunsaturated fatty acid lipoxygenase ALOX12, how selective are they, and which programs against it are still in active trials?

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