Galactoside alpha-(1,2)-fucosyltransferase 1

BE0012830ProteinHumansFUT1

Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO... It is acted on by 1 drug in DrugBank.

Gene name
FUT1
UniProtKB entry
P19526Swiss-Prot
Cellular location
Golgi apparatus, Golgi stack membrane
Residues / weight
365 residues · 41,251 Da
Also known as
Alpha(1,2)FT 1 · Blood group H alpha 2-fucosyltransferase · Fucosyltransferase 1 · GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1 · H

Resolves to

Protein
UniProtP19526UniProt nameFUT1_HUMAN
Gene
HGNCHGNC:4012NCBI Gene2523GeneCardsFUT1
Pharmacology
KEGGhsa:2523
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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19GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Galactoside alpha-(1,2)-fucosyltransferase 1, and which indications are they being tested in?

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