Eukaryotic translation initiation factor 2 subunit 2

BE0012860ProteinHumansEIF2S2

Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). It is acted on by 1 drug in DrugBank.

Gene name
EIF2S2
UniProtKB entry
P20042Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
333 residues · 38,388 Da
Also known as
eIF2-beta · EIF2B · Eukaryotic translation initiation factor 2 subunit beta

Resolves to

Protein
UniProtP20042UniProt nameIF2B_HUMAN
Gene
HGNCHGNC:3266NCBI Gene8894GeneCardsEIF2S2
Pharmacology
KEGGhsa:8894
Structure
PDB6K71PDB6K72PDB6YBV
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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13GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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4+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Eukaryotic translation initiation factor 2 subunit 2, and which indications are they being tested in?

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