Alpha-(1,3)-fucosyltransferase 4

BE0012925ProteinHumansFUT4

Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins (PubMed:1702034, PubMed:1716630, PubMed:29593094). It is acted on by 1 drug in DrugBank.

Gene name
FUT4
UniProtKB entry
P22083Swiss-Prot
Cellular location
Golgi apparatus, Golgi stack membrane
Residues / weight
530 residues · 59,083 Da
Also known as
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase · ELAM-1 ligand fucosyltransferase · ELFT · FCT3A · Fuc-TIV

Resolves to

Protein
UniProtP22083UniProt nameFUT4_HUMAN
Gene
HGNCHGNC:4015NCBI Gene2526GeneCardsFUT4
Pharmacology
KEGGhsa:2526
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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24GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Alpha-(1,3)-fucosyltransferase 4, and which indications are they being tested in?

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