Adenylosuccinate lyase

BE0012967ProteinHumansADSL

Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. It is acted on by 2 drugs in DrugBank.

Gene name
ADSL
UniProtKB entry
P30566Swiss-Prot
Residues / weight
484 residues · 54,889 Da
Also known as
4.3.2.2 · Adenylosuccinase · ADSL · AMPS · ASase

Resolves to

Protein
UniProtP30566UniProt namePUR8_HUMAN
Gene
HGNCHGNC:291NCBI Gene158GeneCardsADSL
Pharmacology
KEGGhsa:158
Structure
PDB2J91PDB2VD6PDB4FFX
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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17GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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2+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Adenylosuccinate lyase, how selective are they, and which programs against it are still in active trials?

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