G protein-coupled receptor kinase 5

BE0013072ProteinHumansGRK5

Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G protein-coupled receptors (GPCRs). It is acted on by 1 drug in DrugBank.

Gene name
GRK5
UniProtKB entry
P34947Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
590 residues · 67,786 Da
Also known as
2.7.11.16 · G protein-coupled receptor kinase GRK5 · GPRK5

Resolves to

Protein
UniProtP34947UniProt nameGRK5_HUMAN
Gene
HGNCHGNC:4544NCBI Gene2869GeneCardsGRK5
Pharmacology
IUPHAR/GtoPdb1469KEGGhsa:2869
Structure
PDB4TNBPDB4TNDPDB6PJX
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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20GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which approved drugs act on G protein-coupled receptor kinase 5, how selective are they, and which programs against it are still in active trials?

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