Potassium citrate is an agent used to manage renal tubular acidosis, hypocitraturic calcium oxalate nephrolithiasis, and uric acid lithiasis with or without calcium stones. Potassium citrate (also known as tripotassium citrate) is a potassium salt of citric acid.
- Mechanism
- Curator reviewed
After oral administration of potassium citrate, its metabolism yields alkaline load. Potassium Citrate therapy appears to increase urinary citrate mainly by modifying the renal handling of citrate, rather than by increasing the filtered load of citrate. In addition to raising urinary pH and citrate, Potassium Citrate increases urinary potassium by approximately the amount contained in the medication. In some patients, Potassium Citrate causes a transient reduction in urinary calcium.
- Primary indication
- For the management of renal tubular acidosis, hypocitraturic calcium oxalate nephrolithiasis, and uric acid lithiasis with or without calcium stones.Curator reviewed · 15 structured indications
- Formula / weight
- C6H5K3O7 · 306.394 g/mol (avg)
- First approval
- Canada, 1998 · United States, 1985 · European Union, 2021
- Also known as
- Potassium citrate anhydrous · Tripotassium citrate
- Code names
- ADV7103-CK
- Brand names
Resolves to
QEEAPRPFLLJWCF-UHFFFAOYSA-KSMILES[K+].[K+].[K+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=OWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Potassium citrate, and which of those have an active Phase 3 trial?
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