Identification

Summary

Potassium citrate is an agent used to manage renal tubular acidosis, hypocitraturic calcium oxalate nephrolithiasis, and uric acid lithiasis with or without calcium stones.

Brand Names
Cytra-K, Urocit-K
Generic Name
Potassium citrate
DrugBank Accession Number
DB09125
Background

Potassium citrate (also known as tripotassium citrate) is a potassium salt of citric acid. It is a white, hygroscopic crystalline powder. It is odorless with a saline taste. It contains 38.3% potassium by mass. In the monohydrate form it is highly hygroscopic and deliquescent. Potassium citrate is used to treat a kidney stone condition called renal tubular acidosis. Potassium Citrate is indicated also for the management of Hypocitraturic calcium oxalate nephrolithiasis.

Type
Small Molecule
Groups
Approved, Investigational, Vet approved
Structure
Weight
Average: 306.394
Monoisotopic: 305.89464697
Chemical Formula
C6H5K3O7
Synonyms
  • Potassium citrate anhydrous
  • Tripotassium citrate

Pharmacology

Indication

For the management of renal tubular acidosis, hypocitraturic calcium oxalate nephrolithiasis, and uric acid lithiasis with or without calcium stones.

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Associated Conditions
Associated Therapies
Contraindications & Blackbox Warnings
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Pharmacodynamics

Potassium citrate induces changes in the urine which renders urine less susceptible to the formation of crystals and stones from salts e.g. calcium oxalate, calcium phosphate and uric acid. Increased citrate levels in the urine will make complexation with calcium which decrease the calcium ion activity and decrease the chance for the formation of calcium phosphate crystals. Citrate also inhibits the spontaneous nucleation of calcium oxalate and calcium phosphate.

Mechanism of action

After oral administration of potassium citrate, its metabolism yields alkaline load. Potassium Citrate therapy appears to increase urinary citrate mainly by modifying the renal handling of citrate, rather than by increasing the filtered load of citrate. In addition to raising urinary pH and citrate, Potassium Citrate increases urinary potassium by approximately the amount contained in the medication. In some patients, Potassium Citrate causes a transient reduction in urinary calcium.

Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism

Potassium Citrate is absorbed and the citrate is metabolised to bicarbonate.

Route of elimination

Urinary; less than 5% unchanged.

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

LD50 (dog): Intravenous 176 mg/kg.

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AbacavirPotassium citrate may increase the excretion rate of Abacavir which could result in a lower serum level and potentially a reduction in efficacy.
AcebutololPotassium citrate may increase the hyperkalemic activities of Acebutolol.
AceclofenacPotassium citrate may increase the excretion rate of Aceclofenac which could result in a lower serum level and potentially a reduction in efficacy.
AcemetacinThe therapeutic efficacy of Potassium citrate can be decreased when used in combination with Acemetacin.
AcetaminophenPotassium citrate may increase the excretion rate of Acetaminophen which could result in a lower serum level and potentially a reduction in efficacy.
Acetylsalicylic acidAcetylsalicylic acid may decrease the excretion rate of Potassium citrate which could result in a higher serum level.
AclidiniumPotassium citrate may increase the excretion rate of Aclidinium which could result in a lower serum level and potentially a reduction in efficacy.
AcrivastinePotassium citrate may increase the excretion rate of Acrivastine which could result in a lower serum level and potentially a reduction in efficacy.
AcyclovirPotassium citrate may increase the excretion rate of Acyclovir which could result in a lower serum level and potentially a reduction in efficacy.
Albutrepenonacog alfaPotassium citrate may increase the excretion rate of Albutrepenonacog alfa which could result in a lower serum level and potentially a reduction in efficacy.
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Food Interactions
  • Take with food. Take potassium citrate within 30 minutes of eating to limit gastrointestinal irritation.

Products

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Product Ingredients
IngredientUNIICASInChI Key
Potassium citrate monohydrateEE90ONI6FF6100-05-6PJAHUDTUZRZBKM-UHFFFAOYSA-K
Active Moieties
NameKindUNIICASInChI Key
Potassium cationionic295O53K15224203-36-9NPYPAHLBTDXSSS-UHFFFAOYSA-N
Citric acidunknownXF417D3PSL77-92-9KRKNYBCHXYNGOX-UHFFFAOYSA-N
Product Images
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Polycitra-KSolution398 mg / 5 mLOralJanssen Pharmaceuticals1996-12-312009-10-02Canada flag
Polycitra-KPowder1.193 g / 4.5 gOralAlza1996-12-312001-08-01Canada flag
Potassium CitrateTablet10 meq/1OralUpsher-Smith Laboratories, LLC2006-09-01Not applicableUS flag
Potassium CitrateTablet5 meq/1OralUpsher-Smith Laboratories, LLC2006-09-01Not applicableUS flag
Urocit-KTablet, extended release10 meq/1OralREMEDYREPACK INC.2016-12-272018-01-19US flag
Urocit-KTablet, extended release15 meq/1OralPhysicians Total Care, Inc.2010-09-15Not applicableUS flag
Urocit-KTablet, extended release15 meq/1OralMission Pharmacal Company2010-01-27Not applicableUS flag
Urocit-KTablet, extended release1080 mgOralMission Pharmacal Company2011-02-11Not applicableCanada flag
Urocit-KTablet, extended release10 meq/1OralMission Pharmacal Company1992-09-01Not applicableUS flag
Urocit-KTablet, extended release10 meq/1OralPhysicians Total Care, Inc.2003-04-17Not applicableUS flag
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Potassium CitrateTablet, extended release10 meq/1OralANI Pharmaceuticals, Inc.2020-03-16Not applicableUS flag
Potassium CitrateTablet, extended release15 meq/1OralCamber Pharmaceuticals, Inc2021-02-15Not applicableUS flag
Potassium CitrateTablet, extended release15 meq/1OralGolden State Medical Supply, Inc.2014-08-06Not applicableUS flag
Potassium CitrateTablet, extended release540 mg/1OralRising Pharmaceuticals, Inc.2006-06-192011-02-03US flag
Potassium CitrateTablet, extended release15 meq/1OralAscent Pharmaceuticals Inc2021-02-15Not applicableUS flag
Potassium CitrateTablet, extended release10 meq/1Oralbryant ranch prepack2020-03-16Not applicableUS flag
Potassium CitrateTablet, extended release10 meq/1Oralbryant ranch prepack2018-05-30Not applicableUS flag
Potassium CitrateTablet, extended release1080 mg/1OralPhysicians Total Care, Inc.2006-07-24Not applicableUS flag
Potassium CitrateTablet, extended release10 meq/1OralAvKARE2020-11-18Not applicableUS flag
Potassium CitrateTablet, extended release15 meq/1OralCadila Healthcare Limited2014-08-12Not applicableUS flag
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
CITRAL SYRUP (PLAIN) 500 mg/5 mlSyrup500 mg/5mlOralSINGAPORE PHARMACEUTICAL PRIVATE LIMITED1991-09-16Not applicable
K Lyte Tab Lime & Orange FlavTablet, effervescent975 mg / tabOralBristol Labs Division Of Bristol Myers Squibb1965-12-311997-08-14Canada flag
Potassium 99mg TabletsTablet99 mg / tabOralBioforce Canada Inc.1994-12-311997-04-14Canada flag
Potassium Tab 99mgTablet99 mg / tabOralDa Vinci Laboratories, Division Of Foodscience Corporation1981-12-311997-05-08Canada flag
Prime's Mixture Potassium CitrateSyrupOralPRIME PHARMACEUTICAL SDN. BHD.2020-09-08Not applicableMalaysia flag
U-ALKALIZER POTASSIUM CITRATE MIXTURESyrup3 g/10mlOralTERAPUTICS SDN BHD2020-09-08Not applicableMalaysia flag
UROCIT-K TABLET 1080 mgTablet1080 mgOralSG HEALTHCARE PTE. LTD.1996-05-27Not applicable
UROCIT-K TABLET 10MEQ (1080MG)Tablet, extended releaseOralSOMEDICO SDN. BHD.2020-09-08Not applicableMalaysia flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
B 6 PlusPotassium citrate (50 mg) + Magnesium oxide (50 mg) + Niacin (20 mg) + Pyridoxine (50 mg) + Riboflavin (2.4 mg) + Thiamine (10 mg)TabletOralAnabolic Laboratories Inc.1967-12-312004-03-15Canada flag
B6 Plus TabPotassium citrate (50 mg) + Magnesium oxide (50 mg) + Niacin (20 mg) + Pyridoxine hydrochloride (50 mg) + Riboflavin (2.4 mg) + Thiamine (10 mg)TabletOralVita Health Products Inc1979-12-312002-08-01Canada flag
C-1000 Plus Zinc & PotassiumPotassium citrate (13 mg) + Calcium ascorbate (1 g) + Potassium aspartate (12 mg) + Zinc ascorbate (5 mg)TabletOralNu Life Nutrition Ltd.1987-12-312005-03-15Canada flag
Cal-mag (one To One) With Potass & ZincPotassium citrate (20 mg / tab) + Calcium citrate (250 mg / tab) + Magnesium oxide (250 mg / tab) + Zinc citrate (5 mg / tab)TabletOralGahler Enterprises Ltd.1988-12-311999-01-27Canada flag
Calcium and Mag-potass and Zinc CapPotassium citrate (10 mg / cap) + Calcium citrate (125 mg / cap) + Magnesium oxide (125 mg / cap) + Zinc citrate (5 mg / cap)CapsuleOralGahler Enterprises Ltd.1991-12-312001-07-26Canada flag
Calcium-magnesium With K & Zn and Vitamin D3Potassium citrate (10 mg) + Calcium citrate (125 mg) + Cholecalciferol (100 unit) + Magnesium oxide (125 mg) + Zinc citrate (5 mg)CapsuleOralHolista Health (Canada) Inc.1997-08-152002-08-06Canada flag
Children's Chewable Vit and Min TabPotassium citrate (5 mg) + Ascorbic acid (100 mg) + Beta carotene (5000 unit) + Biotin (10 mcg) + Calcium citrate (65 mg) + Cholecalciferol (400 unit) + Choline bitartrate (5 mg) + Cyanocobalamin (10 mcg) + Folic acid (.2 mg) + Inositol (5 mg) + Iron (5 mg) + Magnesium (25 mg) + Manganese (1 mg) + Nicotinamide (10 mg) + Calcium pantothenate (10 mg) + Pyridoxine hydrochloride (5 mg) + Riboflavin (5 mg) + Thiamine hydrochloride (5 mg) + Vitamin E (25 unit) + Zinc citrate (2 mg)TabletOralGahler Enterprises Ltd.1990-12-312002-09-11Canada flag
Cmp PlexPotassium citrate (40 mg) + Ascorbic acid (100 mg) + Manganese (5 mg)TabletOralNutraceutical Corporation2003-09-022006-08-02Canada flag
DAILY-ONE 45 FILM TABLETPotassium citrate (18 mg) + Ascorbic acid (90 mg) + Beta carotene (2000 IU) + Biotin (0.06 mg) + Calcium phosphate, tribasic (100 mg) + Calcium phosphate, tribasic (50 mg) + Choline bitartrate (3.9 mg) + Chromium nicotinate (0.13 mg) + Cupric sulfate (2 mg) + Cyanocobalamin (0.015 mg) + Egg phospholipids (23 mg) + Ferrous fumarate (18 mg) + Folic acid (0.4 mg) + Inositol (3.9 mg) + Magnesium oxide (40 mg) + Manganese sulfate (3.5 mg) + Niacin (20 mg) + Pantothenic acid (20 mg) + Potassium Iodide (0.15 mg) + Pyridoxine hydrochloride (12 mg) + Riboflavin (10.2 mg) + Sodium selenite (0.07 mg) + Sodium molybdate (0.05 mg) + Thiamine hydrochloride (9 mg) + Vitamin A acetate (8000 IU) + Vitamin D (400 IU) + Vitamin E (60 IU) + Zinc gluconate (15 mg)Tablet, film coatedFERROSAN SAĞLIK ÜRÜN VE HİZMETLERİ A.Ş.2020-08-14Not applicableTurkey flag
Dual MixPotassium citrate (1.48 mg / g) + Calcium ascorbate (26.0 mg / g)PowderOralOmnilife Manufactura, S.A. De C.V.2003-11-032008-08-20Canada flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
Cytra 3Potassium citrate monohydrate (550 mg/5mL) + Citric acid monohydrate (334 mg/5mL) + Sodium citrate (500 mg/5mL)SyrupOralPegasus Laboratories2006-05-052009-10-17US flag
Cytra 3Potassium citrate monohydrate (550 mg/5mL) + Citric acid monohydrate (334 mg/5mL) + Sodium citrate (500 mg/5mL)SyrupOralCypress Pharmaceuticals, Inc2008-07-292014-10-11US flag
Cytra-KPotassium citrate monohydrate (1100 mg/5mL) + Citric acid monohydrate (334 mg/5mL)SolutionOralCypress Pharmaceutical, Inc.2008-09-302014-10-11US flag
Cytra-K CrystalsPotassium citrate monohydrate (3.3 g/1) + Citric acid monohydrate (1.002 g/1)Granule, for solutionOralCypress Pharmaceutical, Inc.2003-05-01Not applicableUS flag
Lab 52 Essential Oil SensitivePotassium citrate monohydrate (5.53 g/100g) + Sodium fluoride (0.32 g/100g)Paste, dentifriceDentalTOOTHFILM INC2022-05-07Not applicableUS flag
Lab52 Anti-Sensitivity Oral CarePotassium citrate monohydrate (5.4 g/100g) + Calcium lactate (0.2 g/100g) + Xylitol (10 g/100g)AerosolDentalTOOTHFILM INC2022-05-07Not applicableUS flag
Potassium Citrate and Citric AcidPotassium citrate monohydrate (1100 mg/5mL) + Citric acid monohydrate (334 mg/5mL)SolutionOralPharmaceutical Associates, Inc.1997-10-07Not applicableUS flag
Potassium Citrate and Citric AcidPotassium citrate monohydrate (1100 mg/5mL) + Citric acid monohydrate (334 mg/5mL)SolutionOralWestminster Pharmaceuticals, LLC2021-07-21Not applicableUS flag
Potassium Citrate Citric Acid CrystalsPotassium citrate monohydrate (3.3 g/1) + Citric acid monohydrate (1.002 g/1)Granule, for solutionOralVirtus Pharmaceuticals LLC2014-06-132019-04-30US flag
Potassium Citrate-Citric AcidPotassium citrate monohydrate (1100 mg/5mL) + Citric acid monohydrate (334 mg/5mL)SolutionOralMethod Pharmaceuticals, LLC2014-10-202015-12-31US flag

Categories

ATC Codes
A12BA02 — Potassium citrate
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as tricarboxylic acids and derivatives. These are carboxylic acids containing exactly three carboxyl groups.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Tricarboxylic acids and derivatives
Direct Parent
Tricarboxylic acids and derivatives
Alternative Parents
Tertiary alcohols / Carboxylic acid salts / Carboxylic acids / Organic potassium salts / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Alcohol / Aliphatic acyclic compound / Carbonyl group / Carboxylic acid / Carboxylic acid salt / Hydrocarbon derivative / Organic alkali metal salt / Organic oxide / Organic oxygen compound / Organic potassium salt
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
potassium salt (CHEBI:64733)
Affected organisms
  • Humans and other mammals

Chemical Identifiers

UNII
86R1NVR0HW
CAS number
866-84-2
InChI Key
QEEAPRPFLLJWCF-UHFFFAOYSA-K
InChI
InChI=1S/C6H8O7.3K/c7-3(8)1-6(13,5(11)12)2-4(9)10;;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;;/q;3*+1/p-3
IUPAC Name
tripotassium 2-hydroxypropane-1,2,3-tricarboxylate
SMILES
[K+].[K+].[K+].OC(CC([O-])=O)(CC([O-])=O)C([O-])=O

References

General References
  1. Monograph [Link]
  2. safety data sheet [Link]
PubChem Compound
13344
PubChem Substance
310265041
ChemSpider
12775
RxNav
54993
ChEBI
64733
ChEMBL
CHEMBL1200458
Wikipedia
Potassium_citrate
FDA label
Download (81.6 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedTreatmentDuodenal Ulcer Due to Helicobacter Pylori1
4CompletedTreatmentHigh Blood Pressure (Hypertension)1
4CompletedTreatmentKidney Stones / Urolithiasis1
4CompletedTreatmentMetabolic Bone Disorder / Postmenopausal Osteoporosis1
4RecruitingTreatmentHypersensitivity Dentin / Periodontal Disease1
4Unknown StatusPreventionUrolithiasis1
3CompletedTreatmentHealthy Subjects (HS)1
3CompletedTreatmentHypercalciuria / Kidney Stones1
3Not Yet RecruitingPreventionDistal Renal Tubular Acidosis1
3RecruitingTreatmentHigh Blood Pressure (Hypertension)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, powder, for solutionIntramuscular
Injection, solutionIntramuscular
SuppositoryRectal
CapsuleOral
SyrupOral500 mg/5ml
Granule, for solutionOral
Tablet, film coated
PowderOral
Tablet, effervescentOral975 mg / tab
Powder, for solutionOral
GranuleOral2157.3 mg
SyrupOral
TabletOral
Paste, dentifriceDental
AerosolDental
LiquidOral
TabletOral
SolutionOral
Granule, effervescentOral
PowderOral1.193 g / 4.5 g
SolutionOral398 mg / 5 mL
Tablet, effervescentOral
TabletOral99 mg / tab
TabletOral15 meq/1
TabletOral5 meq/1
Tablet, extended releaseOral10 meq/1
Tablet, extended releaseOral1080 mg/1
Tablet, extended releaseOral15 meq/1
Tablet, extended releaseOral5 meq/1
Tablet, extended releaseOral540 mg/1
TabletOral10 meq/1
SolutionOral5 % w/v
For solutionOral
SolutionOral200 mg/5ml
SyrupOral3 g/10ml
SyrupOral
Tablet, extended releaseOral1080 mg
Tablet, extended releaseOral540 mg
Tablet, extended releaseOral
Syrup
SolutionNasal
TabletOral1080 mg
Tablet
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility39.4 mg/mLALOGPS
logP-0.7ALOGPS
logP-1.3ChemAxon
logS-0.89ALOGPS
pKa (Strongest Acidic)3.05ChemAxon
pKa (Strongest Basic)-4.2ChemAxon
Physiological Charge-3ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area140.62 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity68.14 m3·mol-1ChemAxon
Polarizability14.23 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available

Drug created at September 23, 2015 16:41 / Updated at September 29, 2022 07:52