Polycomb complex protein BMI-1

BE0013109ProteinHumansBMI1

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. It is acted on by 1 drug in DrugBank.

Gene name
BMI1
UniProtKB entry
P35226Swiss-Prot
Cellular location
Nucleus
Residues / weight
326 residues · 36,949 Da
Also known as
PCGF4 · Polycomb group RING finger protein 4 · RING finger protein 51 · RNF51

Resolves to

Protein
UniProtP35226UniProt nameBMI1_HUMAN
Gene
HGNCHGNC:1066NCBI Gene648GeneCardsBMI1
Pharmacology
KEGGhsa:648
Structure
PDB2H0DPDB2NA1PDB3RPG
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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25GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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1+ReferenceStructured and connected to the statements they support
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Which compounds in development act on Polycomb complex protein BMI-1, and which indications are they being tested in?

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