Interleukin-12 receptor subunit beta-1

BE0013218ProteinHumansIL12RB1

Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. It is acted on by 5 drugs in DrugBank.

Gene name
IL12RB1
UniProtKB entry
P42701Swiss-Prot
Cellular location
Membrane
Residues / weight
662 residues · 73,108 Da
Also known as
IL-12 receptor beta component · IL-12 receptor subunit beta-1 · IL-12R subunit beta-1 · IL-12R-beta-1 · IL-12RB1

Resolves to

Protein
UniProtP42701UniProt nameI12R1_HUMAN
Gene
HGNCHGNC:5971NCBI Gene3594GeneCardsIL12RB1
Pharmacology
IUPHAR/GtoPdb1715KEGGhsa:3594
Structure
PDB6WDPPDB6WDQPDB8C7M
Drugs

What you can answer from here — as of September 03, 2024

5DrugsApproved to experimental, with action, bond type and pharmacological action
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22GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Interleukin-12 receptor subunit beta-1, and which indications are they being tested in?

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